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FAM131C and MAD1L1
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
FAM131C
MAD1L1
Description
family with sequence similarity 131 member C
mitotic arrest deficient 1 like 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Chromosome
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Nuclear Pore Nuclear Basket
Mitotic Spindle
Mitotic Spindle Pole
MAD1 Complex
Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
Molecular Function
Protein Binding
Protein Binding
Identical Protein Binding
Kinetochore Binding
Biological Process
Mitotic Spindle Assembly Checkpoint Signaling
Negative Regulation Of T Cell Proliferation
Thymus Development
Cell Division
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Regulation Of Metaphase Plate Congression
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Deactivation Of Mitotic Spindle Assembly Checkpoint
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Cognitive performance (
19734545
)
Normal facial asymmetry (angle of surface orientation score) (
30631343
)
Adult body size (
32376654
)
Adverse response to drug (
30420678
)
Age at first birth (
34211149
)
Age at first sexual intercourse (
34211149
27089180
)
Alcohol consumption (drinks per week) (
30643258
)
Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Anxiety (
31906708
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
34002096
28115744
27329760
)
Bitter alcoholic beverage consumption (
31046077
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Coronary artery disease (
29212778
33020668
)
Dimensional psychopathology (Social) (
29496196
)
Disruptive behavior disorder and attention deficit hyperactivity disorder (
33495439
)
Gastroesophageal reflux disease (
34187846
31527586
)
General factor of neuroticism (
30867560
)
Gut microbiota relative abundance (Streptococcus) (
33208821
)
Hand grip strength (
29691431
)
Idiopathic pulmonary fibrosis (
31710517
)
Longevity (
20834067
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
28346444
31624269
)
Myocardial infarction (
33532862
)
Number of sexual partners (
30643258
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Prostate cancer (advanced) (
29892016
)
Refractive error (
32231278
)
Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) (
26503814
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
30285260
22688191
28991256
23974872
29483656
)
Schizophrenia or bipolar disorder (
24280982
)
Schizophrenia, schizoaffective disorder or bipolar disorder (
24166486
)
Sepsis (28-day mortality) (
32592749
)
Sleep duration (short sleep) (
30846698
)
Smoking initiation (
33082346
)
Smoking status (ever vs never smokers) (
30643258
)
Superior frontal gyrus volume (
31530798
)
Superior temporal gyrus volume (
31530798
)
Systolic blood pressure (
30578418
)
Testicular germ cell tumor (
28604732
23666239
28604728
)
Vaginal microbiome composition (Shannon diversity index) (
32723796
)
Interacting Genes
12 interacting genes:
APP
CRYAA
DNAJA3
EWSR1
GRN
HPCAL4
LMO3
MAD1L1
NDN
SFI1
VSNL1
WWP2
63 interacting genes:
ALOX5
AMOTL2
ATG5
BIRC2
CAPN7
CCDC57
CCHCR1
CDC37
CDK18
CIMIP4
COIL
CWF19L2
DRC4
FAM131C
FAM90A1
FXR1
GPKOW
HAUS1
HDAC1
HDAC2
KIF9
LENG1
LGALSL
LMO1
LMO3
LNX1
MAD2L1
MAX
MFAP1
MLX
NDC80
NEBL
NEK2
NINL
NONO
NTAQ1
PIBF1
PML
PPP1R18
PSMA1
RNF8
SIN3A
SIN3B
SPATA18
SPATA2
SUPT5H
SYT17
SYT6
TCAF1
TEX11
TPM1
TPM3
TPR
TRIM29
TSC22D3
TSGA10
TSHZ3
TUBGCP4
UBC
UBTF
USP15
YJU2
ZSCAN32
Entrez ID
348487
8379
HPRD ID
08779
04065
Ensembl ID
ENSG00000185519
ENSG00000002822
Uniprot IDs
Q96AQ9
Q9Y6D9
PDB IDs
1GO4
4DZO
7B1F
7B1H
7B1J
Enriched GO Terms of Interacting Partners
?
Astrocyte Activation Involved In Immune Response
Response To Heat
Astrocyte Activation
Central Nervous System Development
Response To Temperature Stimulus
Negative Regulation Of Signaling
Microglial Cell Activation
Negative Regulation Of Cell Communication
Leukocyte Activation Involved In Inflammatory Response
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Amylin Binding
Negative Regulation Of Protein Localization
Positive Regulation Of Toll Signaling Pathway
Neuron Recognition
Synapse Organization
Protein Stabilization
Positive Regulation Of Aspartic-type Peptidase Activity
MAD1 Complex
Regulation Of Cell Activation
Macrophage Activation
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Signal Transduction
Endosome To Plasma Membrane Transport Vesicle
Negative Regulation Of Signal Transduction
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Regulation Of Protein Stability
Negative Regulation Of Innate Immune Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Protein Folding
Positive Regulation Of Trophectodermal Cell Proliferation
Deactivation Of Mitotic Spindle Assembly Checkpoint
Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
IkappaB Kinase Complex Binding
Type II Interferon Receptor Binding
Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Protein-folding Chaperone Binding
Positive Regulation Of Mitotic Cell Cycle
Response To Norepinephrine
Cytoplasm
Sin3-type Complex
Nucleoplasm
Protein Binding
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Chromatin Binding
Protein Lysine Delactylase Activity
Fungiform Papilla Formation
Positive Regulation Of Cell Cycle Checkpoint
Spindle Assembly
Nuclear Chromosome Segregation
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Muscle Thin Filament Tropomyosin
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Microtubule Cytoskeleton Organization
Hair Follicle Placode Formation
Negative Regulation Of Stem Cell Population Maintenance
Membraneless Organelle Assembly
Mitotic Spindle Assembly Checkpoint Signaling
Regulation Of Mitotic Cell Cycle
Cellular Response To Dopamine
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Chromosome Organization
Intracellular Membraneless Organelle
Negative Regulation Of RNA Metabolic Process
Response To Dopamine
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Mitotic Sister Chromatid Segregation
Stress Fiber
Centrosome
Cytoskeleton
Negative Regulation Of Mitotic Nuclear Division
Sister Chromatid Segregation
Histone Deacetylase Complex
Histone Deacetylase Activity, Hydrolytic Mechanism
Kinetochore
Spindle Organization
Podosome
Nuclear Pore Complex Assembly
Microtubule-based Process
Regulation Of Defense Response
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Binding
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Stem Cell Population Maintenance
Calcium-dependent Phospholipid Binding
Protein Lysine Deacetylase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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