FAM131C and MAD1L1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FAM131C	MAD1L1
Gene Name		family with sequence similarity 131, member C	MAD1 mitotic arrest deficient-like 1 (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Kinetochore Condensed Chromosome Kinetochore Nucleus Nuclear Pore Cytoplasm Centrosome Spindle Cytosol Actin Cytoskeleton Mitotic Spindle
	Molecular Function		Protein Binding
	Biological Process		Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Regulation Of Metaphase Plate Congression
Pathways			Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Cognitive performance ( 19734545)	Bipolar disorder ( 21926972) Longevity ( 20834067) Schizophrenia ( 22688191) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		10 interactors: APP DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1	38 interactors: ALOX5 AMOTL2 BAG5 CCDC94 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PSMA1 RNF8 SIN3A SIN3B SPATA2 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 ZSCAN32
Entrez ID		348487	8379
HPRD ID		08779	04065
Ensembl ID		ENSG00000185519	ENSG00000002822
Uniprot IDs		Q96AQ9	B3KR41 Q9Y6D9
PDB IDs			1GO4 4DZO
Enriched GO Terms of Interacting Partners?		Neuron Recognition Neuromuscular Junction Development Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Metaphase Plate Congression Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Developmental Cell Growth Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Recognition Collateral Sprouting In Absence Of Injury Developmental Growth Involved In Morphogenesis Positive Regulation Of Peptidase Activity Cell Growth Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Proteolysis Synapse Organization Regulation Of Phosphorus Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Axon Choice Point Recognition Activation-induced Cell Death Of T Cells Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Neuron Remodeling Blastocyst Hatching Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Mitochondrial DNA Replication Negative Regulation Of Peptidase Activity Developmental Growth	Negative Regulation Of Gene Expression Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Organelle Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Histone Deacetylation Protein Deacetylation Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Histone Modification Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Modification Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter G2/M Transition Of Mitotic Cell Cycle Cell Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Regulation Of Cell Cycle Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Spindle Checkpoint Transcription, DNA-templated Positive Regulation Of Cell Cycle Chromatin Organization
Tagcloud ?			adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Difference) ?			adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Intersection) ?