FAM131C and HPCAL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		FAM131C	HPCAL4
Description		family with sequence similarity 131 member C	hippocalcin like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Protein Binding	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process		Central Nervous System Development Response To Heat Regulation Of Signal Transduction
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Bone mineral density (Ward's triangle area) ( 27397699)
Interacting Genes		12 interacting genes: APP CRYAA DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1 WWP2	16 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A
Entrez ID		348487	51440
HPRD ID		08779	17113
Ensembl ID		ENSG00000185519	ENSG00000116983
Uniprot IDs		Q96AQ9	B4DGW9 Q9UM19
PDB IDs
Enriched GO Terms of Interacting Partners?		Astrocyte Activation Involved In Immune Response Response To Heat Astrocyte Activation Central Nervous System Development Response To Temperature Stimulus Negative Regulation Of Signaling Microglial Cell Activation Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synapse Organization Protein Stabilization Positive Regulation Of Aspartic-type Peptidase Activity MAD1 Complex Regulation Of Cell Activation Macrophage Activation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Stability Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Deactivation Of Mitotic Spindle Assembly Checkpoint Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine
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