RNF144A and UBE2L6

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid, two hybrid)

		RNF144A	UBE2L6
Gene Name		ring finger protein 144A	ubiquitin-conjugating enzyme E2L 6
Image
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Cytosol
	Molecular Function	Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity ISG15 Transferase Activity
	Biological Process	Protein Ubiquitination	Cellular Protein Modification Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antiviral mechanism by IFN-stimulated genes Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		13 interactors: E2F1 E2F2 E2F3 E2F4 PRKDC UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32	37 interactors: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 LONRF1 MAP3K1 MUL1 PARK2 PJA2 RAD23A RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM8 UBA6 UBA7 UBC UBE3A
Entrez ID		9781	9246
HPRD ID		11510	04867
Ensembl ID		ENSG00000151692	ENSG00000156587
Uniprot IDs		P50876	O14933
PDB IDs		1WIM	1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Lens Fiber Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Catabolic Process Cellular Metabolic Process Apoptotic Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Protein Catabolic Process Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Proteolysis Cellular Protein Metabolic Process Positive Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein K63-linked Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein K48-linked Ubiquitination Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Cellular Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Proteolysis Nitrogen Compound Metabolic Process Regulation Of DNA Repair Protein Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Proteolysis Protein Polyubiquitination Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Metabolic Process Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Protein Monoubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Cytokine Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Viral Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Negative Regulation Of Viral Release From Host Cell Cellular Response To Stimulus Regulation Of Viral Release From Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Apoptotic Process Response To Stimulus Programmed Cell Death Regulation Of Cytokine Production Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Cell Death Regulation Of Kinase Activity Death Cellular Response To Cytokine Stimulus
Tagcloud ?		catalytic cytoplasmic damage damaging dna e3 finger fingers induces insults interacts joining ligase ligases nonhomologous parc parkin persistent pk pkcs promotes prosurvival rbr reversed ring suffer ubiquitination vesicles	btbr c57blks db dba diabesity dissection hlbomdife hllt hyperglycaemia ifi202b inbred introgression jngj lean lep lepr lisch nzo ob obesity outcross pctp positional sorcs1 tallyho tbc1d1 tomosyn zealand zfp69
Tagcloud (Difference) ?		catalytic cytoplasmic damage damaging dna e3 finger fingers induces insults interacts joining ligase ligases nonhomologous parc parkin persistent pk pkcs promotes prosurvival rbr reversed ring suffer ubiquitination vesicles	btbr c57blks db dba diabesity dissection hlbomdife hllt hyperglycaemia ifi202b inbred introgression jngj lean lep lepr lisch nzo ob obesity outcross pctp positional sorcs1 tallyho tbc1d1 tomosyn zealand zfp69
Tagcloud (Intersection) ?