RNF144A and UBE2V2

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		RNF144A	UBE2V2
Description		ring finger protein 144A	ubiquitin conjugating enzyme E2 V2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K6-linked Ubiquitination	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Protein Ubiquitination Error-free Postreplication DNA Repair Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Double-strand Break Repair
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergic rhinitis ( 30013184) Asthma ( 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)	Height ( 31562340)
Interacting Genes		30 interacting genes: BIRC6 CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR HSPA2 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC61A1 SLC7A1 TMEM31 UBC UBE2D1 UBE2D2 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A	32 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 MUL1 RC3H1 RC3H2 RFFL RNF111 RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM5 TRIM54 TRIM63 UBC UBE2N UBE3B XIAP ZNRF1
Entrez ID		9781	7336
HPRD ID		11510	04300
Ensembl ID		ENSG00000151692	ENSG00000169139
Uniprot IDs		P50876	A0M8W4 Q15819
PDB IDs		1WIM 6L99	1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT 7BBD 7BBF 8WR5 9BIV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis TRC Complex Error-free Postreplication DNA Repair Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex DNA-binding Transcription Activator Activity Lens Fiber Cell Apoptotic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Protein Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Dimerization Activity Regulation Of Protein K63-linked Ubiquitination Protein-containing Complex Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Metabolic Process Transferase Activity Ubiquitin-like Protein Transferase Activity Regulation Of DNA Repair Protein Binding Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Targeting To ER Positive Regulation Of Macromolecule Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Positive Regulation Of RNA Biosynthetic Process NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Positive Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Activation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Immune System Process Polkadots Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway
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