RNF144A and E2F2

Number of citations of the paper that reports this interaction (PubMedID 12411495)
42

Data Source:
BioGRID (two hybrid)

		RNF144A	E2F2
Description		ring finger protein 144A	E2F transcription factor 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K6-linked Ubiquitination	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Oxidative Stress Induced Senescence Oncogene Induced Senescence Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Allergic rhinitis ( 30013184) Asthma ( 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)	Eosinophil count ( 27863252 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Sum eosinophil basophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		30 interacting genes: BIRC6 CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR HSPA2 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC61A1 SLC7A1 TMEM31 UBC UBE2D1 UBE2D2 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A	20 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CCNF CDK3 FHL2 GIT2 GNB5 GRB2 KMT5A RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1
Entrez ID		9781	1870
HPRD ID		11510	02692
Ensembl ID		ENSG00000151692	ENSG00000007968
Uniprot IDs		P50876	Q14209
PDB IDs		1WIM 6L99	1N4M
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis TRC Complex Error-free Postreplication DNA Repair Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex DNA-binding Transcription Activator Activity Lens Fiber Cell Apoptotic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Protein Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Dimerization Activity Regulation Of Protein K63-linked Ubiquitination Protein-containing Complex Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Metabolic Process Transferase Activity Ubiquitin-like Protein Transferase Activity Regulation Of DNA Repair Protein Binding Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Targeting To ER Positive Regulation Of Macromolecule Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Positive Regulation Of RNA Biosynthetic Process NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity	Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Rb-E2F Complex Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization G1/S Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Voltage-gated Calcium Channel Activity Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Cell Cycle G1/S Phase Transition Regulation Of DNA Strand Elongation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Transcription Factor Binding Protein Localization To Chromosome DNA Damage Response PcG Protein Complex Transcription Coregulator Activity Positive Regulation Of Metabolic Process BHLH Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Chromosome Organization Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle
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