RNF144A and USP32

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		RNF144A	USP32
Description		ring finger protein 144A	ubiquitin specific peptidase 32
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Deubiquitinase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K6-linked Ubiquitination	Proteolysis Protein Deubiquitination Positive Regulation Of TORC1 Signaling
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Allergic rhinitis ( 30013184) Asthma ( 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)	Interleukin-6 levels ( 33517400)
Interacting Genes		30 interacting genes: BIRC6 CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR HSPA2 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC61A1 SLC7A1 TMEM31 UBC UBE2D1 UBE2D2 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A	13 interacting genes: ANKRD29 DYRK1A MEOX2 MTNR1A NCK2 RAB35 RBCK1 RNF144A TRIM3 TRIM46 TRIM74 UBC ZDHHC17
Entrez ID		9781	84669
HPRD ID		11510	07612
Ensembl ID		ENSG00000151692	ENSG00000170832
Uniprot IDs		P50876	Q8NFA0
PDB IDs		1WIM 6L99
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis TRC Complex Error-free Postreplication DNA Repair Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex DNA-binding Transcription Activator Activity Lens Fiber Cell Apoptotic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Protein Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Dimerization Activity Regulation Of Protein K63-linked Ubiquitination Protein-containing Complex Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Metabolic Process Transferase Activity Ubiquitin-like Protein Transferase Activity Regulation Of DNA Repair Protein Binding Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Targeting To ER Positive Regulation Of Macromolecule Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Positive Regulation Of RNA Biosynthetic Process NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity	Protein Modification Process Histone H3T45 Kinase Activity Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Immune System Process Ubiquitin Protein Ligase Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Anterograde Dense Core Granule Transport
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