ANKHD1 and EIF4ENIF1

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		ANKHD1	EIF4ENIF1
Name		ankyrin repeat and KH domain containing 1	eukaryotic translation initiation factor 4E nuclear import factor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding
	Biological Process	Innate Immune Response	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum immune biomarker levels ( 32066700 )	Age-related hearing impairment ( 24939585 ) Fish- and plant-related diet ( 32066663 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 )
Novel Interactors		None recorded	1 novel interactors: NIN
Interacting Genes		33 interacting genes: ATXN1 ATXN1L BAG4 BCAS2 DMRTB1 EIF3E EIF4A3 EIF4ENIF1 EXOSC8 FHL3 GOLGA2 KRTAP15-1 KRTAP19-5 LENG8 LUC7L2 NFKBIE NOD2 POLR2M PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2B QKI RBFOX2 RBPMS RNF10 TXNL4A UBC YTHDF3 ZNF34 ZNF346	92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6
Entrez ID		54882	56478
HPRD ID		16489	10456
Ensembl ID		ENSG00000131503	ENSG00000184708
Uniprot IDs		Q8IWZ3	Q9NRA8
PDB IDs		Not available	5ANR 6F9W 6X2R
GO Terms Enriched among Interactors		RNA Binding MRNA Binding Regulation Of MRNA Metabolic Process POZ Domain Binding Membraneless Organelle Assembly RNA Metabolic Process MRNA Metabolic Process RNA Processing Negative Regulation Of Translation RNA Splicing Positive Regulation Of Myelination MRNA Splicing, Via Spliceosome Nucleus Regulation Of Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Export Regulation Of Gliogenesis Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly RNA Splicing, Via Transesterification Reactions Regulation Of Nervous System Process Negative Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule MRNA Processing Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Modification Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion P-body Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Maintenance Of ER Location	RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity