ANKHD1 and NFKBIE

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ANKHD1	NFKBIE
Name		ankyrin repeat and KH domain containing 1	NFKB inhibitor epsilon
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Protein Binding Protein Sequestering Activity
	Biological Process	Innate Immune Response	None
Pathways		None	Activation of NF-kappaB in B cells
Diseases		None	Hodgkin lymphoma
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum immune biomarker levels ( 32066700 )	Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Rheumatoid arthritis ( 22446963 23028356 24390342 30423114 32723749 )
Novel Interactors		None recorded	6 novel interactors: BYSL COG7 GUCA1B NPR3 PEX6 POLH
Interacting Genes		33 interacting genes: ATXN1 ATXN1L BAG4 BCAS2 DMRTB1 EIF3E EIF4A3 EIF4ENIF1 EXOSC8 FHL3 GOLGA2 KRTAP15-1 KRTAP19-5 LENG8 LUC7L2 NFKBIE NOD2 POLR2M PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2B QKI RBFOX2 RBPMS RNF10 TXNL4A UBC YTHDF3 ZNF34 ZNF346	15 interacting genes: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1
Entrez ID		54882	4794
HPRD ID		16489	05181
Ensembl ID		ENSG00000131503	ENSG00000146232
Uniprot IDs		Q8IWZ3	O00221 Q7LC14 Q96F31
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		RNA Binding MRNA Binding Regulation Of MRNA Metabolic Process POZ Domain Binding Membraneless Organelle Assembly RNA Metabolic Process MRNA Metabolic Process RNA Processing Negative Regulation Of Translation RNA Splicing Positive Regulation Of Myelination MRNA Splicing, Via Spliceosome Nucleus Regulation Of Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Export Regulation Of Gliogenesis Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly RNA Splicing, Via Transesterification Reactions Regulation Of Nervous System Process Negative Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule MRNA Processing Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Modification Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion P-body Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Maintenance Of ER Location	Non-canonical NF-kappaB Signal Transduction Defense Response Response To External Biotic Stimulus NF-kappaB P50/p65 Complex Canonical NF-kappaB Signal Transduction Immune System Process I-kappaB/NF-kappaB Complex Immune Response Innate Immune Response NF-kappaB Complex Histone Deacetylase Binding Defense Response To Symbiont Defense Response To Other Organism Response To Lipopolysaccharide Cytosol Inflammatory Response Response To Molecule Of Bacterial Origin Cellular Response To Nicotine Ubiquitin Ligase Complex Scaffold Activity Cellular Response To Lipopolysaccharide Regulation Of Interleukin-12 Production Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Cellular Response To Molecule Of Bacterial Origin Protein Lysine Deacetylase Activity Actinin Binding Nucleoplasm Tissue Remodeling Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Negative Regulation Of Myotube Differentiation Response To Other Organism Histone Deacetylase Activity Transcription Cis-regulatory Region Binding Response To Interleukin-6 Regulation Of Transcription By RNA Polymerase II Response To Lipid Protein K48-linked Ubiquitination Nucleus Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation DNA-binding Transcription Activator Activity Response To Angiotensin Response To Cytokine Response To Muscle Stretch