KMT2B and RAP1B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KMT2B	RAP1B
Description		lysine methyltransferase 2B	RAP1B, member of RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL1/2 Complex	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of DNA-templated Transcription	Signal Transduction Small GTPase-mediated Signal Transduction Cell Population Proliferation Calcium-ion Regulated Exocytosis Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Localization In Cell Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Modification Of Postsynaptic Structure Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Formation of WDR5-containing histone-modifying complexes	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)	Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) White blood cell count ( 20139978)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	31 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 DVL2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		9757	5908
HPRD ID		06017	01546
Ensembl ID		ENSG00000272333	ENSG00000127314
Uniprot IDs		A0A669KBI7 Q9UMN6	B7ZAY2 P61224
PDB IDs		3UVM 4ERZ 4PZI 7BRE	3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK 7C7I 7C7J 8SU8 8T09 8T7V
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic MLL1/2 Complex Transcription Initiation-coupled Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process MLL3/4 Complex Nucleoplasm Set1C/COMPASS Complex Intracellular Signaling Cassette Epithelial Cell Differentiation	Ras Protein Signal Transduction Regulation Of Carbohydrate Catabolic Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Regulation Of Purine Nucleotide Metabolic Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Small GTPase-mediated Signal Transduction Regulation Of NADP Metabolic Process Regulation Of JNK Cascade Regulation Of Primary Metabolic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Lipoprotein Transport Cellular Response To Catecholamine Stimulus Response To CAMP Transition Metal Ion Binding Response To Catecholamine Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Glycolytic Process Regulation Of Translation Positive Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Cell Death Programmed Cell Death Response To Radiation Cellular Response To Gamma Radiation Glucose Catabolic Process Signal Transduction Response To Ethanol Regulation Of Cell Communication
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