KMT2B and NREP

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KMT2B	NREP
Description		lysine methyltransferase 2B	neuronal regeneration related protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL1/2 Complex	Cytoplasm
	Molecular Function	DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Protein Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of DNA-templated Transcription	Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Regulation Of Neuron Differentiation
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683) Gut microbiota relative abundance (Sutterella) ( 33208821) Hematocrit ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494 33545615) Plateletcrit ( 27863252 32888494) Reaction time ( 29844566) Red blood cell count ( 29403010 32888494) Thyroid cancer ( 28195142)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	5 interacting genes: ATM EEF1A1 EIF3B IGSF21 KMT2B
Entrez ID		9757	9315
HPRD ID		06017	09545
Ensembl ID		ENSG00000272333	ENSG00000134986
Uniprot IDs		A0A669KBI7 Q9UMN6	Q16612
PDB IDs		3UVM 4ERZ 4PZI 7BRE
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic MLL1/2 Complex Transcription Initiation-coupled Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process MLL3/4 Complex Nucleoplasm Set1C/COMPASS Complex Intracellular Signaling Cassette Epithelial Cell Differentiation
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