KMT2B and RPP14

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KMT2B	RPP14
Description		lysine methyltransferase 2B	ribonuclease P/MRP subunit p14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL1/2 Complex	Nucleus Nucleoplasm Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex Endoribonuclease Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of DNA-templated Transcription	TRNA 5'-leader Removal TRNA Processing
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Formation of WDR5-containing histone-modifying complexes	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)	Height ( 28552196) Hemoglobin levels ( 32327693) Mitochondrial heteroplasmy measurement ( 33731350) Platelet distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	22 interacting genes: A2M ACTN2 ATP5F1B CAPZB DOCK7 EXOSC8 GEMIN2 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ ZNF277
Entrez ID		9757	11102
HPRD ID		06017	18001
Ensembl ID		ENSG00000272333	ENSG00000163684
Uniprot IDs		A0A669KBI7 Q9UMN6	O95059
PDB IDs		3UVM 4ERZ 4PZI 7BRE	6AHR 6AHU
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic MLL1/2 Complex Transcription Initiation-coupled Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process MLL3/4 Complex Nucleoplasm Set1C/COMPASS Complex Intracellular Signaling Cassette Epithelial Cell Differentiation	Ribonuclease MRP Complex Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Nucleolar Ribonuclease P Complex TRNA Metabolic Process RRNA Processing Ribonuclease P Complex TRNA Processing RRNA Metabolic Process RNA Processing Nucleolus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Nucleic Acid Metabolic Process Nucleus Actin Filament Uncapping Ribonuclease MRP Activity
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