CHRM4 and CD59

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM4	CD59
Description		cholinergic receptor muscarinic 4	CD59 molecule (CD59 blood group)
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GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Side Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity	Complement Binding Protein Binding Protein Sequestering Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion	Negative Regulation Of Activation Of Membrane Attack Complex Complement Activation Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Negative Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events	COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs		Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)	Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)
Interacting Genes		22 interacting genes: B2M CBFA2T3 CD59 CD81 CFTR EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 QSOX1 RAB3A RHBDD2 RTN4 SLC60A1 SMIM7 SNCA SYN2 TM7SF2 TSPAN7 YIPF3	16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC TMEM132D
Entrez ID		1132	966
HPRD ID		00330	00117
Ensembl ID		ENSG00000180720	ENSG00000085063
Uniprot IDs		P08173	P13987 Q6FHM9
PDB IDs		5DSG 6D9H 6KP6 7LD3 7LD4 7TRK 7TRP 7TRQ 7TRS 7V68 7V69 7V6A 8E9X 8FX5 8IYH 8IYW 8JER 8JHN	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY 6ZD0 8B0F 8B0G 8B0H 8CN6
Enriched GO Terms of Interacting Partners?		Membrane Neurotransmitter Secretion Regulation Of Chaperone-mediated Autophagy Golgi Membrane Receptor Internalization Synaptic Vesicle Clustering Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Protein Localization Vesicle-mediated Transport In Synapse Endoplasmic Reticulum Membrane Neurotransmitter Transport Transport Vesicle Negative Regulation Of Autophagy Regulated Exocytosis Positive Regulation Of T Cell Cytokine Production Response To Iron Ion Positive Regulation Of Transport Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Leukocyte Mediated Immunity Amyloid Fibril Formation Regulation Of Cytokine Production Involved In Immune Response Lymphocyte Mediated Immunity Golgi Apparatus Regulation Of Aerobic Respiration Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macrophage Fusion Vesicle-mediated Transport Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Cholesterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Autophagy Positive Regulation Of Lipid Kinase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Synaptic Vesicle Calcium-ion Regulated Exocytosis Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport Terminal Bouton Signal Release Vesicle Localization Synaptic Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Membrane	Cell Activation Membrane Attack Complex Regulation Of Immune System Process Other Organism Cell Membrane Membrane Natural Killer Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Effector Process Activation Of Immune Response Complement Activation, GZMK Pathway Negative Regulation Of Adenylate Cyclase Activity Transmembrane Transporter Complex Complement Activation, Alternative Pathway Interleukin-6-mediated Signaling Pathway Plasma Membrane Uterus Development Leukocyte Activation Immune System Process External Side Of Plasma Membrane Negative Regulation Of Striated Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Complement Activation, Classical Pathway Cell Killing Cytotoxic T Cell Differentiation Immune Response-regulating Signaling Pathway Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Creatine:sodium Symporter Activity L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Macrophage Migration Regulation Of Lymphocyte Mediated Immunity Immune Response Cellular Defense Response Lymphocyte Activation Dendrite Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Complement Activation Positive Regulation Of Myeloid Dendritic Cell Activation Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis
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