CHRM4 and EEF1A2

Number of citations of the paper that reports this interaction (PMID 12048193)
4

Data Source:
HPRD (in vivo, in vitro)

		CHRM4	EEF1A2
Gene Name		cholinergic receptor, muscarinic 4	eukaryotic translation elongation factor 1 alpha 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Postsynaptic Membrane	Nucleus Eukaryotic Translation Elongation Factor 1 Complex Neuronal Cell Body
	Molecular Function	G-protein Coupled Acetylcholine Receptor Activity	Translation Elongation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, Nucleic Acid Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell Proliferation Regulation Of Locomotion	Translational Elongation Response To Inorganic Substance Positive Regulation Of Apoptotic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Translation Eukaryotic Translation Elongation
Drugs		Ziprasidone Amitriptyline Olanzapine Metixene Clozapine Trihexyphenidyl Procyclidine Promazine Hyoscyamine Imipramine Darifenacin Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Promethazine Doxepin Desipramine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Solifenacin Isopropamide Fesoterodine Aclidinium
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: EEF1A2 GPRASP1 GRB2	5 interactors: ABTB1 CHRM4 ERG MAPK6 TSPY1
Entrez ID		1132	1917
HPRD ID		00330	04265
Ensembl ID		ENSG00000180720	ENSG00000101210
Uniprot IDs		P08173	Q05639
PDB IDs			3C5J
Enriched GO Terms of Interacting Partners?		Receptor Metabolic Process G-protein Coupled Receptor Catabolic Process	Negative Regulation Of Potassium Ion Export Cell Proliferation Regulation Of Heart Rate By Hormone Adenylate Cyclase-inhibiting G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction By Phosphorylation Gonadal Mesoderm Development Regulation Of Heart Rate By Chemical Signal Peptidyl-histidine Phosphorylation Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport G-protein Coupled Acetylcholine Receptor Signaling Pathway Potassium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Synaptic Transmission Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Membrane Depolarization During Action Potential Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport
Tagcloud ?			2a akt axis cascade chimeric corroborated de elongation eukaryotic hcc hepatocellular homolog lowered mdm4 mechanistic minute mtor oncogene phosphoinositide pi3k protease proteasomal rapamycin strong subset thymoma ubiquitination upregulation
Tagcloud (Difference) ?			2a akt axis cascade chimeric corroborated de elongation eukaryotic hcc hepatocellular homolog lowered mdm4 mechanistic minute mtor oncogene phosphoinositide pi3k protease proteasomal rapamycin strong subset thymoma ubiquitination upregulation
Tagcloud (Intersection) ?