CHRM4 and TM7SF2

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		CHRM4	TM7SF2
Name		cholinergic receptor muscarinic 4	transmembrane 7 superfamily member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane Receptor Complex
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Delta14-sterol Reductase Activity NADP Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via lathosterol
Drugs		Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil	None
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Schizophrenia ( 28991256 29483656 )	No GWAS studies recorded
Interacting Genes		22 interacting genes: B2M CBFA2T3 CD59 CD81 CFTR EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 QSOX1 RAB3A RHBDD2 RTN4 SLC60A1 SMIM7 SNCA SYN2 TM7SF2 TSPAN7 YIPF3	4 interacting genes: CHRM4 CYSRT1 LCE2C RAP2A
Entrez ID		1132	7108
HPRD ID		00330	04564
Ensembl ID		ENSG00000180720	ENSG00000149809
Uniprot IDs		P08173	O76062
PDB IDs		5DSG 6D9H 6KP6 7LD3 7LD4 7TRK 7TRP 7TRQ 7TRS 7V68 7V69 7V6A 8E9X 8FX5 8IYH 8IYW 8JER 8JHN	Not available
GO Terms Enriched among Interactors		Membrane Neurotransmitter Secretion Regulation Of Chaperone-mediated Autophagy Golgi Membrane Receptor Internalization Synaptic Vesicle Clustering Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Protein Localization Vesicle-mediated Transport In Synapse Endoplasmic Reticulum Membrane Neurotransmitter Transport Transport Vesicle Negative Regulation Of Autophagy Regulated Exocytosis Positive Regulation Of T Cell Cytokine Production Response To Iron Ion Positive Regulation Of Transport Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Leukocyte Mediated Immunity Amyloid Fibril Formation Regulation Of Cytokine Production Involved In Immune Response Lymphocyte Mediated Immunity Golgi Apparatus Regulation Of Aerobic Respiration Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macrophage Fusion Vesicle-mediated Transport Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Cholesterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Autophagy Positive Regulation Of Lipid Kinase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Synaptic Vesicle Calcium-ion Regulated Exocytosis Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport Terminal Bouton Signal Release Vesicle Localization Synaptic Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Membrane	G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Rap Protein Signal Transduction Endolysosome Regulation Of Microvillus Assembly Positive Regulation Of Microvillus Assembly Epidermis Development