ULK2 and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 23043107)
55

Data Source:
BioGRID (unspecified method)

		ULK2	GABARAPL2
Description		unc-51 like autophagy activating kinase 2	GABA type A receptor associated protein like 2
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Autophagosome Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Phagophore Assembly Site Membrane	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Signal Transduction Nervous System Development Axonogenesis Axon Guidance Intracellular Protein Localization Regulation Of Autophagy Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Collateral Sprouting Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Somatic Sensory System Development	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Macroautophagy TBC/RABGAPs
Drugs		Fostamatinib
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		15 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32	103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		9706	11345
HPRD ID		10556	16246
Ensembl ID		ENSG00000083290	ENSG00000034713
Uniprot IDs		Q8IYT8	P60520
PDB IDs		6QAT 6QAU 6QAV 6YID	4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Mitophagy Autophagosome Autophagy Of Mitochondrion Response To Mitochondrial Depolarisation Macroautophagy Autophagosome Maturation Autophagosome Membrane Protein Transport Cellular Response To Nitrogen Starvation Intracellular Protein Localization Establishment Of Protein Localization Phosphatidylethanolamine Binding Autophagosome Assembly Regulation Of Protein Complex Stability GABA Receptor Binding Autophagosome Organization Autophagy Protein Import Into Nucleus Import Into Nucleus Protein Localization To Organelle Establishment Of Protein Localization To Organelle Protein-containing Complex Disassembly Phagophore Assembly Site Vacuole Organization Protein Localization To Nucleus Cellular Response To Starvation Beta-tubulin Binding Regulation Of Ras Protein Signal Transduction Protein Targeting Sperm Midpiece Extrinsic Component Of Phagophore Assembly Site Membrane Protein Targeting To Vacuole Response To Starvation Intracellular Protein Transport Nuclear Transport Nucleocytoplasmic Transport Synapse Organization Establishment Of Protein Localization To Vacuole Cellular Response To Nutrient Levels Brown Fat Cell Proliferation Amphisome Extrinsic Component Of Omegasome Membrane Regulation Of Small GTPase Mediated Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Protein K48-linked Ubiquitination Protein Localization To Vacuole Eukaryotic Translation Elongation Factor 1 Complex Organelle Assembly Histone H3K9 Trimethyltransferase Activity	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?