RAPGEF2 and RAP1A

Number of citations of the paper that reports this interaction (PMID 10934204)
24

Data Source:
HPRD (in vitro, in vivo)

		RAPGEF2	RAP1A
Gene Name		Rap guanine nucleotide exchange factor (GEF) 2	RAP1A, member of RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Neuron Projection Neuronal Cell Body Protein Complex Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Kinase Binding Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding Rap GTPase Activator Activity WW Domain Binding Phosphatidic Acid Binding	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding
	Biological Process	MAPK Cascade Blood Vessel Development Neuron Migration G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Ras GTPase Activity Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways			Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs
Diseases
GWAS			Osteoporosis ( 20548944)
Protein-Protein Interactions		12 interactors: ATP8 CTNNB1 HSPA1A KIF5A KIF5B MAGI2 MOB4 NEDD4 RALGDS RAP1A RAP2B SPP1	41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C
Entrez ID		9693	5906
HPRD ID		19358	01545
Ensembl ID		ENSG00000109756	ENSG00000116473
Uniprot IDs		Q9Y4G8	A8KAH9 P62834
PDB IDs			1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis Rap Protein Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neurogenesis Locomotion Nerve Growth Factor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Development Nervous System Development Regulation Of Cell Differentiation Establishment Of Endothelial Barrier Response To Organic Substance Regulation Of Cell Projection Organization Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neuron Differentiation Cell Development Epithelial Cell Development Cellular Response To Growth Factor Stimulus Ras Protein Signal Transduction Neurotrophin Signaling Pathway Response To Growth Factor Negative Regulation Of Signaling Establishment Of Localization In Cell Endothelial Cell Development Regulation Of Signaling Cell Activation Regulation Of Potassium Ion Transport Cell Differentiation Homotypic Cell-cell Adhesion Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Localization Intracellular Transport Intracellular Steroid Hormone Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Response To Stimulus Transport Endothelium Development Positive Regulation Of Neurogenesis Tissue Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Cellular Heat Acclimation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Stress Granule Disassembly Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation
Tagcloud ?		adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 scf skp1 ubiquitylated ubiquitylation	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?		adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 scf skp1 ubiquitylated ubiquitylation	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?		rap1