RAPGEF2 and KIF5B

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		RAPGEF2	KIF5B
Gene Name		Rap guanine nucleotide exchange factor (GEF) 2	kinesin family member 5B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Neuron Projection Neuronal Cell Body Protein Complex Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Microtubule Organizing Center Kinesin Complex Microtubule Membrane Endocytic Vesicle Vesicle Ciliary Rootlet Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Kinase Binding Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding Rap GTPase Activator Activity WW Domain Binding Phosphatidic Acid Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	MAPK Cascade Blood Vessel Development Neuron Migration G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Ras GTPase Activity Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration	Microtubule-based Movement Cytoplasm Organization Axon Guidance Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Cellular Protein Metabolic Process Vesicle Transport Along Microtubule Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS			Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		12 interactors: ATP8 CTNNB1 HSPA1A KIF5A KIF5B MAGI2 MOB4 NEDD4 RALGDS RAP1A RAP2B SPP1	23 interactors: APC CDC5L DTNB GSK3B KIF5A KLC3 KTN1 NCOA2 NDRG1 PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A
Entrez ID		9693	3799
HPRD ID		19358	07214
Ensembl ID		ENSG00000109756	ENSG00000170759
Uniprot IDs		Q9Y4G8	P33176 Q6P164
PDB IDs			1BG2 1MKJ 2P4N 4HNA
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis Rap Protein Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neurogenesis Locomotion Nerve Growth Factor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Development Nervous System Development Regulation Of Cell Differentiation Establishment Of Endothelial Barrier Response To Organic Substance Regulation Of Cell Projection Organization Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neuron Differentiation Cell Development Epithelial Cell Development Cellular Response To Growth Factor Stimulus Ras Protein Signal Transduction Neurotrophin Signaling Pathway Response To Growth Factor Negative Regulation Of Signaling Establishment Of Localization In Cell Endothelial Cell Development Regulation Of Signaling Cell Activation Regulation Of Potassium Ion Transport Cell Differentiation Homotypic Cell-cell Adhesion Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Localization Intracellular Transport Intracellular Steroid Hormone Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Response To Stimulus Transport Endothelium Development Positive Regulation Of Neurogenesis Tissue Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Cellular Heat Acclimation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Stress Granule Disassembly Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Protein Transport Establishment Of Protein Localization Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Development Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Apoptotic Process Mast Cell Activation Programmed Cell Death Regulation Of Intracellular Transport Intracellular Signal Transduction Cell Death Cellular Localization Death Regulation Of Apoptotic Process Intracellular Transport Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Transmission Neurogenesis Positive Regulation Of Signal Transduction Histamine Secretion By Mast Cell Signaling Regulation Of Organelle Organization Nervous System Development Cell Communication Transport Regulation Of Cellular Component Organization Synaptic Vesicle Priming Histamine Secretion
Tagcloud ?		adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 scf skp1 ubiquitylated ubiquitylation	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 scf skp1 ubiquitylated ubiquitylation	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?