TEAD1 and HLA-DMB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TEAD1	HLA-DMB
Description		TEA domain transcription factor 1	major histocompatibility complex, class II, DM beta
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex	Lysosome Lysosomal Membrane Endosome Membrane Late Endosome Membrane MHC Class II Protein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Growth Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of MiRNA Transcription	Adaptive Immune Response Immune System Process MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription	MHC class II antigen presentation
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Central retinal vein equivalent ( 26567291) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diisocyanate-induced asthma ( 25918132) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x loop diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 28552196) Hip circumference adjusted for BMI ( 34021172) HOMA-B (corrected for HOMA-IR) ( 30369944) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Rheumatic heart disease ( 34106200)	A body shape index ( 34021172) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Dermatomyositis ( 27153935) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Squamous cell lung carcinoma ( 28604730) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		20 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 YAP1 ZDHHC17	11 interacting genes: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 PSEN2 TEAD1
Entrez ID		7003	3109
HPRD ID		01802	00831
Ensembl ID		ENSG00000187079	ENSG00000242574
Uniprot IDs		P28347 Q59EF3	A0A1V0E3P2 P28068
PDB IDs		2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5 7CMM 7ZJP 8Q68 9FZA 9GAX	1HDM 2BC4 4FQX 4GBX 4I0P
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Heart Development Positive Regulation Of Metabolic Process Histone Deacetylase Binding Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Developmental Growth Carbon Catabolite Regulation Of Transcription Positive Regulation Of Developmental Growth Regulation Of Growth RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Heart Growth Embryonic Heart Tube Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Female Germ Cell Nucleus Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis Chromatin Cardiac Myofibril Assembly Regulation Of Primary Metabolic Process Transcription Regulator Complex Regulation Of Muscle System Process Regulation Of Organ Growth Positive Regulation Of Growth Trophectodermal Cell Differentiation Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Epithelial Tube Morphogenesis Transcription Coactivator Activity Platelet Formation Muscle Organ Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Peptide Antigen Binding Late Endosome Membrane Lysosomal Membrane Protein-containing Complex Assembly Protein-containing Complex Organization Lysosome Positive Regulation Of Cell Adhesion Endocytic Vesicle Membrane MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Endosome Regulation Of Cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Antigen Processing And Presentation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Cellular Component Assembly Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Multivesicular Body Transport Vesicle Membrane Pigment Granule Maturation Cell Surface MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Regulation Of Cell Activation Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Immune Response ER To Golgi Transport Vesicle Membrane
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