TEAD1

Description		TEA domain transcription factor 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Growth Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of MiRNA Transcription
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Central retinal vein equivalent ( 26567291) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diisocyanate-induced asthma ( 25918132) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x loop diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 28552196) Hip circumference adjusted for BMI ( 34021172) HOMA-B (corrected for HOMA-IR) ( 30369944) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Rheumatic heart disease ( 34106200)
Interacting Genes		20 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 YAP1 ZDHHC17
Entrez ID		7003
HPRD ID		01802
Ensembl ID		ENSG00000187079
Uniprot IDs		P28347 Q59EF3
PDB IDs		2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5 7CMM 7ZJP 8Q68 9FZA 9GAX
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Heart Development Positive Regulation Of Metabolic Process Histone Deacetylase Binding Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Developmental Growth Carbon Catabolite Regulation Of Transcription Positive Regulation Of Developmental Growth Regulation Of Growth RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Heart Growth Embryonic Heart Tube Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Female Germ Cell Nucleus Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis Chromatin Cardiac Myofibril Assembly Regulation Of Primary Metabolic Process Transcription Regulator Complex Regulation Of Muscle System Process Regulation Of Organ Growth Positive Regulation Of Growth Trophectodermal Cell Differentiation Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Epithelial Tube Morphogenesis Transcription Coactivator Activity Platelet Formation Muscle Organ Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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