TEAD1 and MEF2A

Number of citations of the paper that reports this interaction (PMID 12061776)
23

Data Source:
HPRD (in vitro)

		TEAD1	MEF2A
Gene Name		TEA domain family member 1 (SV40 transcriptional enhancer factor)	myocyte enhancer factor 2A
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Gene Expression Hippo Signaling	Mitochondrial Genome Maintenance Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		17 interactors: GCAT HLA-DMB INSR MAX MEF2A MEF2BNB-MEF2B MEF2C MYH7 NCOA1 SRF TBP UBTD1 VGLL1 VGLL2 VGLL4 YAP1 ZDHHC17	26 interactors: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 EP300 ERBB2IP HAND1 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4
Entrez ID		7003	4205
HPRD ID		01802	02807
Ensembl ID		ENSG00000187079	ENSG00000068305
Uniprot IDs		A4FUP2 P28347 Q59EF3	Q02078
PDB IDs		2HZD 3KYS	1C7U 1EGW 1LEW 3KOV 3MU6 3P57
Enriched GO Terms of Interacting Partners?		Heart Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Developmental Growth Embryonic Heart Tube Morphogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Heart Tube Development Platelet Formation Positive Regulation Of Growth Platelet Morphogenesis Biosynthetic Process Cardiac Myofibril Assembly Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A RNA Metabolic Process Heart Development Transcription From RNA Polymerase II Promoter Regulation Of Developmental Growth Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Muscle Cell Fate Determination Gene Expression Striated Muscle Tissue Development Regulation Of RNA Metabolic Process Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Cardiac Chamber Development Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Behavioral Fear Response Positive Regulation Of Organ Growth Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Tissue Development Ventricular Cardiac Myofibril Assembly Smooth Muscle Cell Differentiation Cardiac Muscle Tissue Development Heart Looping Determination Of Heart Left/right Asymmetry Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Cell Development Embryonic Organ Development	Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Skeletal Muscle Tissue Development Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Tissue Development Response To Organic Substance Regulation Of Cell Development Cardiovascular System Development Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Striated Muscle Tissue Development Response To Abiotic Stimulus Skeletal Muscle Tissue Development System Development Cellular Macromolecule Biosynthetic Process Developmental Process
Tagcloud ?		520d 5p biomaterial cd105 combinatorial convert converted dedifferentiation demethylation elavl2 fibroblasts gatad2b hsa ipscs lost microrna mir mscs never pluripotent safely stemness survived transfectants transfection transfections tumorigenicity turned usefulness	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Difference) ?		520d 5p biomaterial cd105 combinatorial convert converted dedifferentiation demethylation elavl2 fibroblasts gatad2b hsa ipscs lost microrna mir mscs never pluripotent safely stemness survived transfectants transfection transfections tumorigenicity turned usefulness	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Intersection) ?