TEAD1 and MYH7

Number of citations of the paper that reports this interaction (PMID 12861002)
21

Data Source:
HPRD (two hybrid, in vitro)

		TEAD1	MYH7
Gene Name		TEA domain family member 1 (SV40 transcriptional enhancer factor)	myosin, heavy chain 7, cardiac muscle, beta
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus	Stress Fiber Nucleoplasm Cytoplasm Muscle Myosin Complex Focal Adhesion Myosin Complex Sarcomere Z Disc Myosin Filament
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Gene Expression Hippo Signaling	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Muscle Contraction Striated Muscle Contraction Adult Heart Development Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Height ( 20881960)	Resting heart rate ( 20639392)
Protein-Protein Interactions		17 interactors: GCAT HLA-DMB INSR MAX MEF2A MEF2BNB-MEF2B MEF2C MYH7 NCOA1 SRF TBP UBTD1 VGLL1 VGLL2 VGLL4 YAP1 ZDHHC17	4 interactors: KXD1 TEAD1 TEAD3 TEAD4
Entrez ID		7003	4625
HPRD ID		01802	01175
Ensembl ID		ENSG00000187079	ENSG00000092054
Uniprot IDs		A4FUP2 P28347 Q59EF3	P12883
PDB IDs		2HZD 3KYS	1IK2 2FXM 2FXO 3DTP 4DB1
Enriched GO Terms of Interacting Partners?		Heart Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Developmental Growth Embryonic Heart Tube Morphogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Heart Tube Development Platelet Formation Positive Regulation Of Growth Platelet Morphogenesis Biosynthetic Process Cardiac Myofibril Assembly Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A RNA Metabolic Process Heart Development Transcription From RNA Polymerase II Promoter Regulation Of Developmental Growth Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Muscle Cell Fate Determination Gene Expression Striated Muscle Tissue Development Regulation Of RNA Metabolic Process Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Cardiac Chamber Development Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Behavioral Fear Response Positive Regulation Of Organ Growth Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Tissue Development Ventricular Cardiac Myofibril Assembly Smooth Muscle Cell Differentiation Cardiac Muscle Tissue Development Heart Looping Determination Of Heart Left/right Asymmetry Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Cell Development Embryonic Organ Development	Positive Regulation Of Stem Cell Maintenance Regulation Of Stem Cell Maintenance Hippo Signaling Positive Regulation Of Stem Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Cell Development Regulation Of Cell Development Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Female Pregnancy Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Lateral Mesoderm Development Transcription, DNA-templated Notochord Development RNA Biosynthetic Process Trophectodermal Cell Differentiation Paraxial Mesoderm Development Positive Regulation Of Cellular Metabolic Process Blastocyst Formation RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Embryonic Heart Tube Morphogenesis Cellular Macromolecule Biosynthetic Process Embryo Implantation Embryo Development Macromolecule Biosynthetic Process Embryonic Heart Tube Development Cell Fate Specification Blastocyst Development Reproductive Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Mesoderm Development Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		520d 5p biomaterial cd105 combinatorial convert converted dedifferentiation demethylation elavl2 fibroblasts gatad2b hsa ipscs lost microrna mir mscs never pluripotent safely stemness survived transfectants transfection transfections tumorigenicity turned usefulness	5188delaga aggregates alert autosomal biopsies cd3 cd68 cd8 comprising contained distal endomysial inclusion k1729del laing member mhc myopathy myositis p62 pathologic perivascular physicians possibility rimmed smi specimen typical vacuoles
Tagcloud (Difference) ?		520d 5p biomaterial cd105 combinatorial convert converted dedifferentiation demethylation elavl2 fibroblasts gatad2b hsa ipscs lost microrna mir mscs never pluripotent safely stemness survived transfectants transfection transfections tumorigenicity turned usefulness	5188delaga aggregates alert autosomal biopsies cd3 cd68 cd8 comprising contained distal endomysial inclusion k1729del laing member mhc myopathy myositis p62 pathologic perivascular physicians possibility rimmed smi specimen typical vacuoles
Tagcloud (Intersection) ?