PDCD2 and TBC1D21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDCD2	TBC1D21
Description		programmed cell death 2	TBC1 domain family member 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Exosome	Acrosomal Vesicle Cytoplasm Cytoskeleton Cytoplasmic Vesicle Extracellular Exosome Sperm Midpiece
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Actin Binding GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	Spermatogenesis Sperm Axoneme Assembly Cell Differentiation Flagellated Sperm Motility Plasma Membrane To Endosome Transport Sperm Mitochondrial Sheath Assembly Regulation Of Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)	Coffee consumption (cups per day) ( 31837886) Estimated glomerular filtration rate ( 31152163) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Feeling fed-up ( 29500382) Glucose homeostasis traits ( 25524916) LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		7 interacting genes: ERRFI1 HCFC1 LSM8 NCOR1 NFKBIB PRKN TBC1D21	29 interacting genes: APP CCDC158 CFAP53 EVI5L GAS2 GFAP GTF2E1 KIF26A KRT15 KRT35 KRT37 KRT38 KRT40 LCN2 MEOX2 NR1D2 NUTM1 PDCD2 PMF1 PMF1-BGLAP RAB3IP REL RIBC1 SAMD4A SEPTIN2 SNX7 STMN3 TCF12 TIMM10
Entrez ID		5134	161514
HPRD ID		02922	15473
Ensembl ID		ENSG00000071994	ENSG00000167139
Uniprot IDs		A0A087WYJ3 F5H4V9 J3QK82 Q16342	Q8IYX1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Phosphorus Metabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of ATP Metabolic Process Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Response To Glucocorticoid Negative Regulation Of Intralumenal Vesicle Formation Negative Regulation Of Kinase Activity Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Kinase Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SH3 Domain Binding Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Histone Deacetylase Binding Response To Curcumin Negative Regulation Of Phosphorylation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of JNK Cascade Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Response To Corticosteroid Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Regulation Of MAPK Cascade Negative Regulation Of Catalytic Activity Release From Viral Latency Type 2 Mitophagy Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Regulation Of Synaptic Vesicle Transport Sperm Mitochondrial Sheath Assembly Lewy Body Regulation Of Spontaneous Synaptic Transmission Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake	Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Keratin Filament Cytoskeleton Structural Molecule Activity Regulation Of Cell Projection Organization Astrocyte Projection Morphogenesis Of An Epithelium Negative Regulation Of Cell Projection Organization Regulation Of Neurotransmitter Uptake Epithelial Cell Differentiation Tissue Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonemal A Tubule Inner Sheath
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