PDCD2 and HCFC1

Number of citations of the paper that reports this interaction (PMID 12149646)
16

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PDCD2	HCFC1
Gene Name		programmed cell death 2	host cell factor C1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicular Exosome	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Mitochondrion Membrane Neuronal Cell Body Set1C/COMPASS Complex SAGA-type Complex MLL5-L Complex MLL1 Complex
	Molecular Function	DNA Binding Protein Binding Enzyme Binding Metal Ion Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Identical Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Cell Cycle Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein Complex Assembly Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization
Pathways			Chromatin modifying enzymes Organelle biogenesis and maintenance Chromatin organization Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Mitochondrial biogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: HCFC1 LSM8 NCOR1 NFKBIB PARK2	31 interactors: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIN3A SP1 TAF9 THAP11 THAP7 YY1 ZBTB17
Entrez ID		5134	3054
HPRD ID		02922	02061
Ensembl ID		ENSG00000071994	ENSG00000172534
Uniprot IDs		E9PCU7 F5GYS7 Q16342	P51610
PDB IDs			4GO6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of JNK Cascade Negative Regulation Of Stress-activated MAPK Cascade RNA Metabolic Process Gene Expression Protein Stabilization Regulation Of Lipid Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Nucleobase-containing Compound Metabolic Process Regulation Of Protein Stability Regulation Of Anion Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Release From Viral Latency Regulation Of Carbohydrate Metabolic Process Transcription, DNA-templated Negative Regulation Of MAPK Cascade Cellular Nitrogen Compound Metabolic Process Regulation Of JNK Cascade RNA Biosynthetic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Regulation Of Stress-activated MAPK Cascade Nitrogen Compound Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Definitive Erythrocyte Differentiation Cellular Response To Manganese Ion Regulatory T Cell Differentiation Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Degradation Dopamine Transport Cellular Macromolecule Biosynthetic Process Aggresome Assembly Macromolecule Biosynthetic Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Cellular Process Rhythmic Process Negative Regulation Of Cellular Metabolic Process Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Metabolic Process Cellular Response To Stress Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Initiation Response To Oxidative Stress Cellular Response To Organic Substance Circadian Rhythm Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Regulation Of Cell Proliferation
Tagcloud ?		aberrant aimed alters antitumor arrest atm blotting carcinogenesis chk1 conserved contribute gastric immunohistochemistry investigate line mkn28 mkn45 mutated nude p53 phase poor programmed qrt skin specimens suppressed ultraviolet uvb	capd3 capg2 condensin conjunction demethylase demethylases dismissal e2f1 ever expanding h3k27me2 h3k4me2 h3k9me1 h4k20me1 intimate jmjc jumonji ncapd3 ncapg2 phd phf8 prophase recognizing removing seq set1a setd1a smc
Tagcloud (Difference) ?		aberrant aimed alters antitumor arrest atm blotting carcinogenesis chk1 conserved contribute gastric immunohistochemistry investigate line mkn28 mkn45 mutated nude p53 phase poor programmed qrt skin specimens suppressed ultraviolet uvb	capd3 capg2 condensin conjunction demethylase demethylases dismissal e2f1 ever expanding h3k27me2 h3k4me2 h3k9me1 h4k20me1 intimate jmjc jumonji ncapd3 ncapg2 phd phf8 prophase recognizing removing seq set1a setd1a smc
Tagcloud (Intersection) ?