ABCB5

Description		ATP binding cassette subfamily B member 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Eye Development Cell Differentiation Regulation Of Membrane Potential Xenobiotic Transport Transmembrane Transport
Pathways		ABC-family proteins mediated transport
Drugs		Biricodar Dofequidar
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 34103634 32296059 31959851 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23259602) Eosinophil count ( 29403010) Femur bone mineral density x serum urate levels interaction ( 34046847) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Prostate cancer ( 23535732) Response to statin therapy ( 20339536) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: CCND2 CD44 EPHA2 ERBB2 FGFR4 PSMB5 RAF1 STK11
Entrez ID		340273
HPRD ID		12402
Ensembl ID		ENSG00000004846
Uniprot IDs		Q2M3G0
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Kinase Activity Positive Regulation Of Catalytic Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Phosphorylation Phosphorylation Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Schwann Cell Development Lamellipodium Membrane Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Epithelial Cell Proliferation Regulation Of Catalytic Activity Receptor Complex Carbohydrate Homeostasis Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Phosphate-containing Compound Metabolic Process ATP Binding Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Growth Factor Binding Cell Population Proliferation Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Positive Regulation Of Phosphate Metabolic Process Apoptotic Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Glial Cell Development Negative Regulation Of Programmed Cell Death Nucleotide Binding Transferase Activity Notochord Cell Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Wound Healing Positive Regulation Of Protein Modification Process
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