AKAP12 and ADRBK1

Number of citations of the paper that reports this interaction (PMID 11309381)
22

Data Source:
HPRD (in vitro, in vivo)

		AKAP12	ADRBK1
Gene Name		A kinase (PRKA) anchor protein 12	adrenergic, beta, receptor kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex	Cytoplasm Cytosol Plasma Membrane Membrane Primary Cilium
	Molecular Function	Protein Binding Adenylate Cyclase Binding Protein Kinase A Binding	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Protein Targeting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of CAMP Biosynthetic Process Regulation Of Protein Kinase C Signaling	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Receptor Internalization Positive Regulation Of Catecholamine Secretion Termination Of G-protein Coupled Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Striated Muscle Contraction Neurotrophin TRK Receptor Signaling Pathway Cardiac Muscle Contraction
Pathways			G alpha (q) signalling events Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Hedgehog 'on' state Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Calmodulin induced events Downstream signal transduction PLC-gamma1 signalling Signaling by Hedgehog Signaling by EGFR in Cancer Activation of SMO
Drugs			Adenosine triphosphate
Diseases
GWAS		Chronic myeloid leukemia ( 21540461)
Protein-Protein Interactions		6 interactors: ADRB2 ADRBK1 EGFR FHL1 PRKAR2A PRKCA	47 interactors: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB1 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		9590	156
HPRD ID		05263	00182
Ensembl ID		ENSG00000131016	ENSG00000173020
Uniprot IDs		Q02952 Q86TJ9	P25098
PDB IDs			1BAK 3CIK 3KRW 3KRX 3V5W
Enriched GO Terms of Interacting Partners?		Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Muscle Contraction Response To Growth Factor Positive Regulation Of Catalytic Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Muscle Contraction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Activation Of Adenylate Cyclase Activity Positive Regulation Of Phosphorylation Regulation Of The Force Of Heart Contraction Activation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Vasodilation Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Lyase Activity Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Immune Response Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation	Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Communication Signaling Platelet Activation Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To External Stimulus Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Metabolic Process Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Cell Activation Regulation Of Body Fluid Levels Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Wound Healing Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase Activity Response To Wounding
Tagcloud ?		actin blotting compromised cytoskeletal diverse finding gossypol gynecological hippo hoc1a lats1 mediating organization ovarian phosphopeptides phosphoproteins phosphoproteomic phosphorylates platinum qpcr recurs ser showing traditional untreated upregulation urgently valuable yap1	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
Tagcloud (Difference) ?		actin blotting compromised cytoskeletal diverse finding gossypol gynecological hippo hoc1a lats1 mediating organization ovarian phosphopeptides phosphoproteins phosphoproteomic phosphorylates platinum qpcr recurs ser showing traditional untreated upregulation urgently valuable yap1	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
Tagcloud (Intersection) ?