MAD2L1BP and IGSF21

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAD2L1BP	IGSF21
Gene Name		MAD2L1 binding protein	immunoglobin superfamily, member 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Spindle Intracellular Membrane-bounded Organelle	Extracellular Region
	Molecular Function	Protein Binding
	Biological Process	Mitotic Cell Cycle Checkpoint Regulation Of Exit From Mitosis
Pathways
Drugs
Diseases
GWAS			Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		15 interactors: EEF1A1 HOMEZ IGSF21 INPP5K KAT5 KIAA1377 KRT15 LRIF1 MAD2L1 NMI PTN SETDB1 TP53 TRIP13 ZBTB14	32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		9587	84966
HPRD ID		10065	11309
Ensembl ID		ENSG00000124688	ENSG00000117154
Uniprot IDs		Q15013	Q96ID5
PDB IDs		2QYF
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Double-strand Break Repair Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Chromosome Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Renal Water Transport Negative Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Organelle Organization Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of Glycogen (starch) Synthase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of APC-Cdc20 Complex Activity Cell Cycle Process Regulation Of Gene Expression In Utero Embryonic Development Regulation Of Transcription From RNA Polymerase II Promoter Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate	Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth
Tagcloud ?		allelic analytical coexpression coordinator datasets esrp2 exemplifies fgfr2 gbp1 glud2 illustrates impairs indels landscape maged1 mtap overlaid principle proof r353q revealing signatures slc30a8 splicing substitution tbnc tnbc tpp1 transcriptome
Tagcloud (Difference) ?		allelic analytical coexpression coordinator datasets esrp2 exemplifies fgfr2 gbp1 glud2 illustrates impairs indels landscape maged1 mtap overlaid principle proof r353q revealing signatures slc30a8 splicing substitution tbnc tnbc tpp1 transcriptome
Tagcloud (Intersection) ?