MAD2L1BP and MAD2L1

Number of citations of the paper that reports this interaction (PMID 12456649)
35

Data Source:
HPRD (in vivo, two hybrid)

		MAD2L1BP	MAD2L1
Gene Name		MAD2L1 binding protein	MAD2 mitotic arrest deficient-like 1 (yeast)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Spindle Intracellular Membrane-bounded Organelle	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nuclear Pore Cytosol Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Cell Cycle Checkpoint Regulation Of Exit From Mitosis	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of APC-Cdc20 Complex Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			F-cell distribution ( 21326311) HIV-1 viral setpoint ( 22174851)
Protein-Protein Interactions		15 interactors: EEF1A1 HOMEZ IGSF21 INPP5K KAT5 KIAA1377 KRT15 LRIF1 MAD2L1 NMI PTN SETDB1 TP53 TRIP13 ZBTB14	20 interactors: ADAM17 ANAPC2 APP CDC16 CDC20 CDC27 CSF2RB ESR2 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TSC22D4 UBD
Entrez ID		9587	4085
HPRD ID		10065	03274
Ensembl ID		ENSG00000124688
Uniprot IDs		Q15013	Q13257
PDB IDs		2QYF	1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Double-strand Break Repair Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Chromosome Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Renal Water Transport Negative Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Organelle Organization Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of Glycogen (starch) Synthase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of APC-Cdc20 Complex Activity Cell Cycle Process Regulation Of Gene Expression In Utero Embryonic Development Regulation Of Transcription From RNA Polymerase II Promoter Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate	Regulation Of Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Mitotic Cell Cycle Checkpoint Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Regulation Of Cellular Component Organization Mitotic Nuclear Division Negative Regulation Of Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Processing Regulation Of Chromosome Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Protein Processing Negative Regulation Of Protein Ubiquitination Regulation Of Proteolysis Cell Division Negative Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		allelic analytical coexpression coordinator datasets esrp2 exemplifies fgfr2 gbp1 glud2 illustrates impairs indels landscape maged1 mtap overlaid principle proof r353q revealing signatures slc30a8 splicing substitution tbnc tnbc tpp1 transcriptome	aimed amplification aurka aurkb auroras banding bm carried cdc20 cellularity checkpoint chromosomal cytogenetics developing differ emphasizes fish hematologic hypercellular hypocellular instability logistic malignancies mds mitotic normo qrt solid spindle
Tagcloud (Difference) ?		allelic analytical coexpression coordinator datasets esrp2 exemplifies fgfr2 gbp1 glud2 illustrates impairs indels landscape maged1 mtap overlaid principle proof r353q revealing signatures slc30a8 splicing substitution tbnc tnbc tpp1 transcriptome	aimed amplification aurka aurkb auroras banding bm carried cdc20 cellularity checkpoint chromosomal cytogenetics developing differ emphasizes fish hematologic hypercellular hypocellular instability logistic malignancies mds mitotic normo qrt solid spindle
Tagcloud (Intersection) ?