VPS4B and CHMP2A

Number of citations of the paper that reports this interaction (PubMedID 15173323)
0

Data Source:
HPRD (two hybrid, in vitro)

		VPS4B	CHMP2A
Description		vacuolar protein sorting 4 homolog B	charged multivesicular body protein 2A
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nuclear Pore Cytoplasm Endosome Centrosome Cytosol Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome Flemming Body ATPase Complex	Autophagosome Membrane Kinetochore Chromatin ESCRT III Complex Nucleus Nuclear Envelope Nuclear Pore Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding
	Biological Process	Angiogenesis Plasma Membrane Repair Potassium Ion Transport Autophagy Nucleus Organization Endosome Organization Vacuole Organization Vacuolar Transport Lysosomal Transport Mitotic Metaphase Chromosome Alignment Central Nervous System Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Cholesterol Transport Nuclear Membrane Reassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Canonical Wnt Signaling Pathway Establishment Of Blood-brain Barrier Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation ESCRT III Complex Disassembly	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Protein Polymerization Protein Homooligomerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)	Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		10 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 OGT VPS4A ZFYVE19	14 interacting genes: CHMP3 DOCK8 E2F4 EIF2B5 MITD1 NOL4 SNCA STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B
Entrez ID		9525	27243
HPRD ID		15653	12520
Ensembl ID		ENSG00000119541	ENSG00000130724
Uniprot IDs		O75351	M0R1T5 O43633
PDB IDs		1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y 7L9X	7ZCG 7ZCH
Enriched GO Terms of Interacting Partners?		Midbody Abscission Mitotic Cytokinetic Process ESCRT III Complex Disassembly ESCRT Complex Disassembly Cytokinetic Process Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Viral Budding Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Membrane Fission Multivesicular Body-lysosome Fusion Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Lysosomal Membrane Organization Metaphase Chromosome Alignment Membrane Assembly Midbody Kinetochore Microtubule Chromosome Localization Regulation Of Mitotic Spindle Assembly Endosome Organization Nuclear Pore Nucleus Organization Multivesicular Body Membrane Vesicle Fusion Organelle Membrane Fusion Regulation Of Spindle Assembly Plasma Membrane Organization Lysosomal Transport Autophagy Organelle Fusion Regulation Of Mitotic Spindle Organization Protein-containing Complex Disassembly Multivesicular Body Viral Process Regulation Of Centrosome Duplication Membrane Fusion	Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Cytokinetic Process Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane K63-linked Deubiquitinase Activity Late Endosome To Lysosome Transport Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Regulation Of Exosomal Secretion Midbody Endosome Organization Nuclear Membrane Reassembly Cytoskeleton-dependent Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Viral Process Late Endosome Membrane Positive Regulation Of Secretion Biological Process Involved In Interaction With Host Endosome To Lysosome Transport Metaphase Chromosome Alignment Membrane Assembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Cytokinesis ATPase Complex Regulation Of Exocytosis Regulation Of Secretion Chromosome Localization Positive Regulation Of Exocytosis Positive Regulation Of Exosomal Secretion Nuclear Pore Protein Domain Specific Binding Cysteine-type Deubiquitinase Activity Nucleus Organization Protein Deubiquitination
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