VPS4B and VPS4A

Number of citations of the paper that reports this interaction (PMID 11563910)
22

Data Source:
HPRD (two hybrid)

		VPS4B	VPS4A
Gene Name		vacuolar protein sorting 4 homolog B (S. cerevisiae)	vacuolar protein sorting 4 homolog A (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome Flemming Body	ESCRT III Complex Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Flemming Body
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity ATPase Activity ATPase Activity, Coupled	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled
	Biological Process	Cell Separation After Cytokinesis Potassium Ion Transport Nucleus Organization Endosome Organization Vacuole Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Viral Process Endosomal Transport Viral Life Cycle Cytoplasmic Microtubule Organization Intracellular Cholesterol Transport Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Viral Process Negative Regulation Of Cell Death Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation	Cytokinesis Cell Separation After Cytokinesis Nucleus Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Protein Transport Viral Process Vesicle-mediated Transport Endosomal Transport Viral Life Cycle Cytoplasmic Microtubule Organization Negative Regulation Of Cytokinesis Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 VPS4A ZFYVE19	9 interactors: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C NPC1 RND2 VPS4B
Entrez ID		9525	27183
HPRD ID		15653	11676
Ensembl ID		ENSG00000119541	ENSG00000132612
Uniprot IDs		O75351	Q9UN37
PDB IDs		1WR0 1XWI 2CPT 2JQH 2JQK	1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Assembly Establishment Of Chromosome Localization Regulation Of Spindle Assembly Regulation Of Mitotic Spindle Organization Mitotic Sister Chromatid Segregation Regulation Of Cell Division Sister Chromatid Segregation Nucleus Organization Regulation Of Cell Cycle Cell Division Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Regulation Of Cell Cycle Process Chromosome Segregation Vacuolar Transport Mitotic Nuclear Division Establishment Of Organelle Localization Regulation Of Mitotic Nuclear Division Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Mitotic Cell Cycle Process Mitotic Cell Cycle Abscission Viral Budding Via Host ESCRT Complex Regulation Of Protein Complex Assembly Regulation Of Organelle Organization Viral Budding Negative Regulation Of Cytokinesis Chromosome Organization Regulation Of Mitotic Cell Cycle Cytokinesis Cell Cycle Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Cell Cycle Regulation Of Cytoskeleton Organization Cell Cycle Protein Transport Viral Life Cycle Establishment Of Protein Localization Virion Assembly Intracellular Transport Endosomal Transport Organelle Organization Protein Localization Regulation Of Cellular Component Organization	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Mitotic Metaphase Plate Congression Regulation Of Spindle Assembly Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Regulation Of Centrosome Duplication Nucleus Organization Regulation Of Centrosome Cycle Viral Budding Via Host ESCRT Complex Chromosome Segregation Positive Regulation Of Viral Release From Host Cell Viral Budding Regulation Of Mitotic Nuclear Division Mitotic Nuclear Division Establishment Of Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Organelle Localization Cell Division Regulation Of Viral Release From Host Cell Virion Assembly Regulation Of Cell Division Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Process Regulation Of Protein Complex Assembly Mitotic Cell Cycle Establishment Of Protein Localization Regulation Of Mitotic Cell Cycle Intracellular Transport Viral Life Cycle Regulation Of Organelle Organization Regulation Of Cell Cycle Process Endosomal Transport Regulation Of Cytoskeleton Organization Chromosome Organization Positive Regulation Of Viral Process Cell Cycle Process Negative Regulation Of Macroautophagy Membrane Budding Protein Localization Regulation Of Cellular Component Organization Establishment Of Localization In Cell Cell Cycle Protein Transport Cellular Localization
Tagcloud ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pard6b pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify wizened	aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww
Tagcloud (Difference) ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pard6b pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify wizened	aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 ww
Tagcloud (Intersection) ?		vps4b