VPS4B and ZFYVE19

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, biochemical)

		VPS4B	ZFYVE19
Description		vacuolar protein sorting 4 homolog B	zinc finger FYVE-type containing 19
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nuclear Pore Cytoplasm Endosome Centrosome Cytosol Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome Flemming Body ATPase Complex	Cytoplasm Centrosome Cytoskeleton Midbody Cleavage Furrow Flemming Body
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding Zinc Ion Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding
	Biological Process	Angiogenesis Plasma Membrane Repair Potassium Ion Transport Autophagy Nucleus Organization Endosome Organization Vacuole Organization Vacuolar Transport Lysosomal Transport Mitotic Metaphase Chromosome Alignment Central Nervous System Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Cholesterol Transport Nuclear Membrane Reassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Canonical Wnt Signaling Pathway Establishment Of Blood-brain Barrier Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation ESCRT III Complex Disassembly	Negative Regulation Of Cytokinesis Mitotic Cytokinesis Checkpoint Signaling Cell Division Midbody Abscission
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061)
Interacting Genes		10 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 OGT VPS4A ZFYVE19	10 interacting genes: AXIN1 CAPN7 CCHCR1 DPY30 HTT MITD1 TRIM55 TRIM63 VPS4B ZDHHC17
Entrez ID		9525	84936
HPRD ID		15653	15731
Ensembl ID		ENSG00000119541	ENSG00000166140
Uniprot IDs		O75351	Q96K21
PDB IDs		1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y 7L9X
Enriched GO Terms of Interacting Partners?		Midbody Abscission Mitotic Cytokinetic Process ESCRT III Complex Disassembly ESCRT Complex Disassembly Cytokinetic Process Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Viral Budding Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Membrane Fission Multivesicular Body-lysosome Fusion Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Lysosomal Membrane Organization Metaphase Chromosome Alignment Membrane Assembly Midbody Kinetochore Microtubule Chromosome Localization Regulation Of Mitotic Spindle Assembly Endosome Organization Nuclear Pore Nucleus Organization Multivesicular Body Membrane Vesicle Fusion Organelle Membrane Fusion Regulation Of Spindle Assembly Plasma Membrane Organization Lysosomal Transport Autophagy Organelle Fusion Regulation Of Mitotic Spindle Organization Protein-containing Complex Disassembly Multivesicular Body Viral Process Regulation Of Centrosome Duplication Membrane Fusion	Identical Protein Binding Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Cytokinetic Process Intracellular Transport Multivesicular Body Sorting Pathway P53 Binding Cellular Localization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Localization In Cell Beta-catenin Destruction Complex Assembly Axial Mesoderm Formation Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Organelle Assembly Canonical Wnt Signaling Pathway Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of CAMKK-AMPK Signaling Cascade MIT Domain Binding
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