SYTL4 and STXBP1

Number of citations of the paper that reports this interaction (PMID 15563604)
19

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		SYTL4	STXBP1
Gene Name		synaptotagmin-like 4	syntaxin binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Centrosome Plasma Membrane Synaptic Vesicle Extrinsic Component Of Membrane Secretory Granule Transport Vesicle Membrane	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Platelet Alpha Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Phospholipid Binding Zinc Ion Binding Rab GTPase Binding Neurexin Family Protein Binding	SNARE Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	Intracellular Protein Transport Exocytosis Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway	Platelet Degranulation Energy Reserve Metabolic Process Vesicle Docking Involved In Exocytosis Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Maturation Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion Protein Stabilization Long Term Synaptic Depression Platelet Aggregation Protein Localization To Plasma Membrane
Pathways			Integration of energy metabolism Regulation of insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CCDC85B CEP70 FXR2 HMG20A INS RAB27A RAB27B RAB3A RAB8A STX1A STXBP1 ZBTB7B	27 interactors: APBA1 APBA2 APP CDK5 CDK5R1 DOC2A DOC2B DYT10 HGS MAPT NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SQSTM1 STX11 STX19 STX1A STX1B STX2 STX3 SYTL4 TRIM38 USO1
Entrez ID		94121	6812
HPRD ID		06735	04235
Ensembl ID		ENSG00000102362	ENSG00000136854
Uniprot IDs		A8K973 B2R7R4 Q71SF7 Q96C24	B7Z1V5 P61764 Q68CM6
PDB IDs		2CSZ 3FDW
Enriched GO Terms of Interacting Partners?		Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Regulation Of Exocytosis Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Transport Establishment Of Organelle Localization Positive Regulation Of Secretion Exocytosis Regulation Of Secretion Regulation Of Vesicle-mediated Transport Rab Protein Signal Transduction Organelle Localization Secretion By Cell Regulation Of Cellular Localization Neurotransmitter Secretion Glutamate Secretion Secretion Protein Secretion Regulation Of Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Positive Regulation Of Transport Regulation Of Synaptic Vesicle Transport Neurotransmitter Transport Multivesicular Body Sorting Pathway Cell-cell Signaling Synaptic Vesicle Exocytosis Vesicle Organization Acid Secretion Ras Protein Signal Transduction Regulation Of Neurotransmitter Secretion Synaptic Transmission Regulation Of Synaptic Vesicle Priming Dicarboxylic Acid Transport Regulation Of Synaptic Transmission Synaptic Vesicle Maturation Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Energy Reserve Metabolic Process Positive Regulation Of Regulated Secretory Pathway Intracellular Protein Transport Neuromuscular Synaptic Transmission Amino Acid Transport Regulation Of Synaptic Plasticity Melanosome Transport	Synaptic Transmission Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Secretion Synaptic Vesicle Transport Cell-cell Signaling Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Secretion By Cell Neurotransmitter Transport Vesicle Fusion Establishment Of Vesicle Localization Vesicle Localization Secretion Establishment Of Organelle Localization Cellular Localization Exocytosis Organelle Fusion Vesicle Docking Intracellular Transport Membrane Docking Organelle Localization Membrane Fusion Protein Localization Regulation Of Exocytosis Regulation Of Cellular Localization Protein Transport Membrane Organization Establishment Of Protein Localization Intracellular Protein Transport Signaling Transport Cell Communication Vesicle Organization Positive Regulation Of Exocytosis Vesicle-mediated Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Peptidyl-threonine Phosphorylation Regulation Of Secretion Axon Cargo Transport Regulation Of Signaling Organelle Organization Positive Regulation Of Secretion Histone H3-T6 Phosphorylation Neurofilament Bundle Assembly Positive Regulation Of Transport Serine Phosphorylation Of STAT3 Protein Nervous System Development Regulation Of Synaptic Vesicle Transport
Tagcloud ?		acot2 adiponectin anxa2 asah3l atherogenic brought carry cyp7a1 enpp6 ginseng ginsenosides hfd hmgcs1 il1rn insig1 korean krge lipa mogat1 obesity osbpl3 physiology pla2g4e plscr4 profoundly saponin slc27a3 triglycerides vldlr	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Difference) ?		acot2 adiponectin anxa2 asah3l atherogenic brought carry cyp7a1 enpp6 ginseng ginsenosides hfd hmgcs1 il1rn insig1 korean krge lipa mogat1 obesity osbpl3 physiology pla2g4e plscr4 profoundly saponin slc27a3 triglycerides vldlr	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Intersection) ?