SYTL4 and RAB27B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		SYTL4	RAB27B
Description		synaptotagmin like 4	RAB27B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Platelet Alpha Granule Membrane Cytoplasmic Vesicle Exocytic Vesicle	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Protein Binding Phospholipid Binding Zinc Ion Binding Small GTPase Binding Neurexin Family Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Plasma Membrane Repair Intracellular Protein Transport Exocytosis Insulin Secretion Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		Platelet degranulation	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		29 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SNCA SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 TUBA1A ZBTB7B ZBTB9 ZRANB1	10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D
Entrez ID		94121	5874
HPRD ID		06735	04846
Ensembl ID		ENSG00000102362	ENSG00000041353
Uniprot IDs		A8K973 B2R7R4 Q71SF7 Q96C24	O00194
PDB IDs		2CSZ 3FDW 5X6T	2F7S
Enriched GO Terms of Interacting Partners?		Myosin V Binding Positive Regulation Of Exocytosis Regulation Of Synaptic Plasticity Exocytosis Vesicle-mediated Transport In Synapse Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Secretion By Cell Regulation Of Exocytosis Positive Regulation Of Secretion Modulation Of Chemical Synaptic Transmission Secretion Secretion By Cell Synaptic Vesicle Exocytosis Secretory Granule Regulated Exocytosis SNARE Complex Assembly Identical Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Regulation Of Secretion By Cell Positive Regulation Of Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Regulation Of Secretion Organelle Localization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Calcium-ion Regulated Exocytosis GTP Binding Regulation Of Vesicle Fusion Establishment Of Vesicle Localization Synaptic Vesicle Transport Vesicle Docking Involved In Exocytosis Postsynapse Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Synaptic Vesicle Endocytosis Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Transport Positive Regulation Of Transport Vesicle Localization Presynaptic Endocytosis Synaptic Vesicle Membrane Synaptic Vesicle Maturation Establishment Of Organelle Localization Regulation Of Cellular Component Organization Vesicle-mediated Transport Synapse	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?