SYTL4 and RAB27A

Number of citations of the paper that reports this interaction (PubMedID 11865063)
38

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SYTL4	RAB27A
Description		synaptotagmin like 4	RAB27A, member RAS oncogene family
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Platelet Alpha Granule Membrane Cytoplasmic Vesicle Exocytic Vesicle	Photoreceptor Outer Segment Extracellular Region Lysosome Endosome Late Endosome Golgi Apparatus Cytosol Membrane Apical Plasma Membrane Secretory Granule Dendrite Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Phospholipid Binding Zinc Ion Binding Small GTPase Binding Neurexin Family Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Plasma Membrane Repair Intracellular Protein Transport Exocytosis Insulin Secretion Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair	Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Vesicle-mediated Transport Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Pigmentation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Pigment Granule Localization Pigment Granule Transport Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways		Platelet degranulation	Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)	Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		29 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SNCA SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 TUBA1A ZBTB7B ZBTB9 ZRANB1	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		94121	5873
HPRD ID		06735	04845
Ensembl ID		ENSG00000102362	ENSG00000069974
Uniprot IDs		A8K973 B2R7R4 Q71SF7 Q96C24	A2RU94 P51159
PDB IDs		2CSZ 3FDW 5X6T	6HUF 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
Enriched GO Terms of Interacting Partners?		Myosin V Binding Positive Regulation Of Exocytosis Regulation Of Synaptic Plasticity Exocytosis Vesicle-mediated Transport In Synapse Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Secretion By Cell Regulation Of Exocytosis Positive Regulation Of Secretion Modulation Of Chemical Synaptic Transmission Secretion Secretion By Cell Synaptic Vesicle Exocytosis Secretory Granule Regulated Exocytosis SNARE Complex Assembly Identical Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Regulation Of Secretion By Cell Positive Regulation Of Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Regulation Of Secretion Organelle Localization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Calcium-ion Regulated Exocytosis GTP Binding Regulation Of Vesicle Fusion Establishment Of Vesicle Localization Synaptic Vesicle Transport Vesicle Docking Involved In Exocytosis Postsynapse Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Synaptic Vesicle Endocytosis Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Transport Positive Regulation Of Transport Vesicle Localization Presynaptic Endocytosis Synaptic Vesicle Membrane Synaptic Vesicle Maturation Establishment Of Organelle Localization Regulation Of Cellular Component Organization Vesicle-mediated Transport Synapse	Small GTPase Binding Intracellular Transport Establishment Of Localization In Cell Secretion By Cell Exocytosis Intracellular Protein Transport Cellular Localization Protein Transport Exocytic Vesicle Vesicle-mediated Transport Neurexin Family Protein Binding Secretion Establishment Of Protein Localization Intracellular Protein Localization Regulation Of Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Exocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Melanosome Positive Regulation Of Secretion Synaptic Vesicle Docking Positive Regulation Of Regulated Secretory Pathway Regulation Of Nervous System Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Vesicle Docking Regulation Of Transport Signal Release Organelle Localization By Membrane Tethering Organelle Localization Myosin Binding Positive Regulation Of Establishment Of Protein Localization Membrane Docking Regulation Of Hormone Levels Neurotransmitter Transport Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Regulated Exocytosis Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Transport Protein Localization To Extracellular Region
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