SYTL4 and RAB8A

Number of citations of the paper that reports this interaction (PubMedID 11773082)
0

Data Source:
HPRD (in vivo, in vitro)

		SYTL4	RAB8A
Description		synaptotagmin like 4	RAB8A, member RAS oncogene family
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Platelet Alpha Granule Membrane Cytoplasmic Vesicle Exocytic Vesicle	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosome Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Membrane Trans-Golgi Network Transport Vesicle Dendrite Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Ciliary Base Non-motile Cilium Glutamatergic Synapse
	Molecular Function	Protein Binding Phospholipid Binding Zinc Ion Binding Small GTPase Binding Neurexin Family Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding Protein Tyrosine Kinase Binding
	Biological Process	Plasma Membrane Repair Intracellular Protein Transport Exocytosis Insulin Secretion Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair	Exocytosis Vesicle Docking Involved In Exocytosis Autophagy Golgi Organization Axonogenesis Regulation Of Autophagy Protein Transport Cell Projection Organization Endocytic Recycling Cellular Response To Insulin Stimulus Regulation Of Protein Localization Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		Platelet degranulation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)	Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		29 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SNCA SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 TUBA1A ZBTB7B ZBTB9 ZRANB1	23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC
Entrez ID		94121	4218
HPRD ID		06735	01296
Ensembl ID		ENSG00000102362	ENSG00000167461
Uniprot IDs		A8K973 B2R7R4 Q71SF7 Q96C24	P61006
PDB IDs		2CSZ 3FDW 5X6T	3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6WHE 6YX5 6ZSI 6ZSJ 7BWT 7LWB 9IKQ
Enriched GO Terms of Interacting Partners?		Myosin V Binding Positive Regulation Of Exocytosis Regulation Of Synaptic Plasticity Exocytosis Vesicle-mediated Transport In Synapse Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Secretion By Cell Regulation Of Exocytosis Positive Regulation Of Secretion Modulation Of Chemical Synaptic Transmission Secretion Secretion By Cell Synaptic Vesicle Exocytosis Secretory Granule Regulated Exocytosis SNARE Complex Assembly Identical Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Regulation Of Secretion By Cell Positive Regulation Of Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Regulation Of Secretion Organelle Localization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Calcium-ion Regulated Exocytosis GTP Binding Regulation Of Vesicle Fusion Establishment Of Vesicle Localization Synaptic Vesicle Transport Vesicle Docking Involved In Exocytosis Postsynapse Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Synaptic Vesicle Endocytosis Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Transport Positive Regulation Of Transport Vesicle Localization Presynaptic Endocytosis Synaptic Vesicle Membrane Synaptic Vesicle Maturation Establishment Of Organelle Localization Regulation Of Cellular Component Organization Vesicle-mediated Transport Synapse	Small GTPase Binding Establishment Of Protein Localization Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Localization Cytoplasmic Vesicle Golgi To Plasma Membrane Transport Secretion By Cell Endosome Trans-Golgi Network Recycling Endosome Membrane Secretion Polyubiquitin Modification-dependent Protein Binding Spontaneous Neurotransmitter Secretion Intracellular Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Intracellular Signal Transduction Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Positive Regulation Of Protein Localization Golgi Vesicle Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytosol Membrane Interleukin-2-mediated Signaling Pathway Spindle Pole Organelle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Neurexin Family Protein Binding Signal Transduction Organelle Localization By Membrane Tethering Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Positive Regulation Of Protein Export From Nucleus Membrane Docking Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization To Membrane Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Cilium Assembly Regulation Of Cell Projection Assembly K63-linked Polyubiquitin Modification-dependent Protein Binding Establishment Of Vesicle Localization
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