EIF4E2 and CARD9

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF4E2	CARD9
Gene Name		eukaryotic translation initiation factor 4E family member 2	caspase recruitment domain family, member 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol MRNA Cap Binding Complex	Cytoplasm
	Molecular Function	RNA Cap Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Protein Homodimerization Activity CARD Domain Binding
	Biological Process	In Utero Embryonic Development Translational Initiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway	Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Drug Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS		Non-small cell lung cancer ( 21079520)	Ankylosing spondylitis ( 21743469) Crohn's disease ( 22936669 21102463) Inflammatory bowel disease ( 23128233) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661) Ulcerative colitis ( 19915572 20228799 21297633)
Protein-Protein Interactions		44 interactors: ADAMTSL4 AES AMOTL2 APP ARIH1 CARD9 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 GIGYF1 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MIPOL1 MYOG NECAB2 NOTCH2NL PRDM14 REL SPAG5 SPERT SPRY2 TADA2A TCF4 TMCC2 TRIM27 TRIM54 UBXN11 USHBP1 USP54 ZBTB9	65 interactors: ABLIM1 AES ALS2CR11 AMOTL2 BCL10 BLZF1 C1orf94 CCDC36 CCDC85B CCHCR1 CDCA7L CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DUSP13 EIF4E2 FAM124B FAM161A FAM208B FAM50B HMBOX1 IQCE KCTD9 KIAA0408 KIF9 KRT19 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 LENG1 LMO1 LZTS2 MEOX2 MFAP1 NECAB2 PAK7 PBX2 PHC2 PNMA5 PPP1R18 RTP5 SSX2IP STX11 SUMO1 TCEANC TCL1A TFIP11 TNFAIP1 TRIM23 TRIM29 TRIM42 TRIM54 TSNAX USP15 VPS28 ZCCHC7 ZNF250 ZNF417 ZNF572 ZNF587 ZNF655
Entrez ID		9470	64170
HPRD ID		05798	06236
Ensembl ID		ENSG00000135930	ENSG00000187796
Uniprot IDs		B4E1E4 B8ZZL3 O60573 Q53RG0	Q9H257
PDB IDs		2JGB 2JGC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Binding Negative Regulation Of Gene Expression Regulation Of Protein Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Response To Stimulus Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Translational Initiation Response To Organic Substance Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Positive Regulation Of Cell Cycle Regulation Of Protein Localization Signal Transduction Regulation Of Kinase Activity Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Phosphorus Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Fate Commitment Positive Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Regulation Of Wnt Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stimulus Histone H3-R26 Methylation Positive Regulation Of Muscle Atrophy Inner Cell Mass Cell Fate Commitment Cell Communication	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Organelle Organization Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Developmental Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Wnt Signaling Pathway Spliceosomal Complex Disassembly Organelle Assembly Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Mast Cell Cytokine Production Histone H2B Conserved C-terminal Lysine Deubiquitination Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		abundant accumulated arabidopsis cdnas cerevisiae complementation complemented conditional deduced floral grew homologous iso isogenic mammals mapping monocotyledonous mrnas northern organs roots saccharomyces specialization thaliana yac yeast zone	adapter assembly danger defense discuss engaged framework fungal homeostasis inducible innate lectin links lymphoid lymphoma malt mucosa multifunctional nonredundant oligomerization paracaspase polymorphisms responds rig rlrs sensors spleen syk
Tagcloud (Difference) ?		abundant accumulated arabidopsis cdnas cerevisiae complementation complemented conditional deduced floral grew homologous iso isogenic mammals mapping monocotyledonous mrnas northern organs roots saccharomyces specialization thaliana yac yeast zone	adapter assembly danger defense discuss engaged framework fungal homeostasis inducible innate lectin links lymphoid lymphoma malt mucosa multifunctional nonredundant oligomerization paracaspase polymorphisms responds rig rlrs sensors spleen syk
Tagcloud (Intersection) ?