EIF4E2 and SPAG5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF4E2	SPAG5
Gene Name		eukaryotic translation initiation factor 4E family member 2	sperm associated antigen 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol MRNA Cap Binding Complex	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Midbody Microtubule Plus-end Mitotic Spindle
	Molecular Function	RNA Cap Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Translational Initiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Non-small cell lung cancer ( 21079520)
Protein-Protein Interactions		44 interactors: ADAMTSL4 AES AMOTL2 APP ARIH1 CARD9 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 GIGYF1 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MIPOL1 MYOG NECAB2 NOTCH2NL PRDM14 REL SPAG5 SPERT SPRY2 TADA2A TCF4 TMCC2 TRIM27 TRIM54 UBXN11 USHBP1 USP54 ZBTB9	35 interactors: AMOTL2 ARNT2 ATN1 BARD1 C1orf109 CCDC33 CCHCR1 CDC20B CDK1 CHCHD3 DCX EIF4E2 EIF4ENIF1 FBXO28 FMR1 GOLGA8EP GOLGA8F HAUS1 IQCE KANSL1 LGALS14 LINGO1 ODF1 ORC6 POLR2L RBM41 SH2D4A SMARCE1 SNAP47 SNAPIN TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZMAT2
Entrez ID		9470	10615
HPRD ID		05798	10246
Ensembl ID		ENSG00000135930	ENSG00000076382
Uniprot IDs		B4E1E4 B8ZZL3 O60573 Q53RG0	Q96R06
PDB IDs		2JGB 2JGC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Binding Negative Regulation Of Gene Expression Regulation Of Protein Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Response To Stimulus Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Translational Initiation Response To Organic Substance Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Positive Regulation Of Cell Cycle Regulation Of Protein Localization Signal Transduction Regulation Of Kinase Activity Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Phosphorus Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Fate Commitment Positive Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Regulation Of Wnt Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stimulus Histone H3-R26 Methylation Positive Regulation Of Muscle Atrophy Inner Cell Mass Cell Fate Commitment Cell Communication	Organelle Fusion Negative Regulation Of Gene Expression Synaptic Vesicle Fusion To Presynaptic Membrane Membrane Fusion Negative Regulation Of Cellular Metabolic Process Developmental Process Multicellular Organismal Development Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Positive Regulation Of Late Endosome To Lysosome Transport Pronuclear Fusion Nervous System Development Vesicle Fusion Synaptic Vesicle Exocytosis Negative Regulation Of Biosynthetic Process Negative Regulation Of MRNA 3'-end Processing Central Nervous System Development Regulation Of Glial Cell Differentiation Terminal Button Organization Autophagic Vacuole Maturation Negative Regulation Of Translation
Tagcloud ?		abundant accumulated arabidopsis cdnas cerevisiae complementation complemented conditional deduced floral grew homologous iso isogenic mammals mapping monocotyledonous mrnas northern organs roots saccharomyces specialization thaliana yac yeast zone	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst exosc3 hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b synapt tryptic unsupervised urgent
Tagcloud (Difference) ?		abundant accumulated arabidopsis cdnas cerevisiae complementation complemented conditional deduced floral grew homologous iso isogenic mammals mapping monocotyledonous mrnas northern organs roots saccharomyces specialization thaliana yac yeast zone	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst exosc3 hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b synapt tryptic unsupervised urgent
Tagcloud (Intersection) ?