HAND2 and NPM1

Number of citations of the paper that reports this interaction (PMID 11812799)
10

Data Source:
HPRD (two hybrid)

		HAND2	NPM1
Gene Name		heart and neural crest derivatives expressed 2	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex Protein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription AT DNA Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Thymus Development Peripheral Nervous System Neuron Development Palate Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Pathways			Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CENPB COPS5 EP300 GATA4 HAND1 HEY2 HEYL NPM1 PHOX2A PPP2R5D PRKACA PRKCA TCF3 TCF4	53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1
Entrez ID		9464	4869
HPRD ID		03872	01246
Ensembl ID		ENSG00000164107	ENSG00000181163
Uniprot IDs		P61296	P06748
PDB IDs			2LLH 2P1B 2VXD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Muscle Structure Development Positive Regulation Of Transcription, DNA-templated Cardiovascular System Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cardiac Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Ventricle Morphogenesis Tissue Development Anatomical Structure Morphogenesis Cardiac Right Ventricle Morphogenesis Atrioventricular Valve Morphogenesis Regulation Of Metabolic Process Cardiac Septum Development Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Atrioventricular Valve Development Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Binding Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Regulation Of Cell Cycle Organ Development Striated Muscle Tissue Development Heart Valve Morphogenesis Heart Valve Development Muscle Tissue Development Transcription, DNA-templated Histone H3-T6 Phosphorylation Tissue Morphogenesis Epithelium Development System Development Energy Reserve Metabolic Process Cardiac Chamber Development RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Embryo Development Regulation Of Nucleic Acid-templated Transcription Tube Development Regulation Of RNA Biosynthetic Process Regulation Of Heart Contraction	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin prevents progesterone proliferative simple stroma stromal suppress weak	aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Difference) ?		absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin prevents progesterone proliferative simple stroma stromal suppress weak	aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Intersection) ?