HAND2 and PPP2R5D

Number of citations of the paper that reports this interaction (PMID 14636580)
35

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		HAND2	PPP2R5D
Gene Name		heart and neural crest derivatives expressed 2	protein phosphatase 2, regulatory subunit B, delta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex Protein Complex	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription AT DNA Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	Angiogenesis In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Thymus Development Peripheral Nervous System Neuron Development Palate Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process Nervous System Development Pathogenesis Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Stress-activated MAPK Cascade
Pathways			Signaling by GPCR Integration of energy metabolism misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids Toll Like Receptor 7/8 (TLR7/8) Cascade APC truncation mutants have impaired AXIN binding Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane DARPP-32 events XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CENPB COPS5 EP300 GATA4 HAND1 HEY2 HEYL NPM1 PHOX2A PPP2R5D PRKACA PRKCA TCF3 TCF4	9 interactors: CHEK2 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C SGOL1 USHBP1
Entrez ID		9464	5528
HPRD ID		03872	09039
Ensembl ID		ENSG00000164107	ENSG00000112640
Uniprot IDs		P61296	Q14738
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Muscle Structure Development Positive Regulation Of Transcription, DNA-templated Cardiovascular System Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cardiac Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Ventricle Morphogenesis Tissue Development Anatomical Structure Morphogenesis Cardiac Right Ventricle Morphogenesis Atrioventricular Valve Morphogenesis Regulation Of Metabolic Process Cardiac Septum Development Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Atrioventricular Valve Development Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Binding Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Regulation Of Cell Cycle Organ Development Striated Muscle Tissue Development Heart Valve Morphogenesis Heart Valve Development Muscle Tissue Development Transcription, DNA-templated Histone H3-T6 Phosphorylation Tissue Morphogenesis Epithelium Development System Development Energy Reserve Metabolic Process Cardiac Chamber Development RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Embryo Development Regulation Of Nucleic Acid-templated Transcription Tube Development Regulation Of RNA Biosynthetic Process Regulation Of Heart Contraction	Cardiac Right Ventricle Formation Cardiac Ventricle Formation Cardiac Chamber Formation Cartilage Morphogenesis Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Apoptotic Process Involved In Development Developmental Programmed Cell Death Negative Regulation Of DNA Binding Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Cardiac Ventricle Morphogenesis Embryonic Heart Tube Development Regulation Of DNA Binding Embryonic Heart Tube Formation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Negative Regulation Of Binding Odontogenesis Of Dentin-containing Tooth Cardiac Ventricle Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiac Left Ventricle Formation Cell Proliferation Involved In Outflow Tract Morphogenesis Visceral Serous Pericardium Development Odontogenesis Cardiac Chamber Development Apoptotic Process Involved In Heart Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Cartilage Development Mesenchyme Development Centriole-centriole Cohesion Norepinephrine Biosynthetic Process Heart Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Coronary Artery Morphogenesis Noradrenergic Neuron Differentiation Apoptotic Process Connective Tissue Development Programmed Cell Death Regulation Of Binding Positive Regulation Of Transcription Regulatory Region DNA Binding Cell Death Death Negative Regulation Of Stress Fiber Assembly
Tagcloud ?		absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin prevents progesterone proliferative simple stroma stromal suppress weak	altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Difference) ?		absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin progesterone proliferative simple stroma stromal suppress weak	altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Intersection) ?		prevents