HAND2 and PHOX2A

Number of citations: 0 (PubMedID 14506227)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		HAND2	PHOX2A
Name		heart and neural crest derivatives expressed 2	paired like homeobox 2A
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Outflow Tract Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Differentiation Regulation Of Tissue Remodeling Norepinephrine Biosynthetic Process Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Thymus Development Embryonic Skeletal System Development Peripheral Nervous System Neuron Development Roof Of Mouth Development Mesenchyme Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Determination Of Heart Left/right Asymmetry Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Positive Regulation Of P38MAPK Cascade Primary Palate Development Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway	Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Somatic Motor Neuron Differentiation Oculomotor Nerve Formation Trochlear Nerve Formation Locus Ceruleus Development Midbrain Development Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Parasympathetic Nervous System Development Neuron Development Dopaminergic Neuron Differentiation
Pathways		Transcriptional regulation by RUNX2 Cardiogenesis	None
Diseases		None	Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Atrial fibrillation ( 28416822 29892015 30061737 33990960 ) Chin dimples ( 27182965 ) Early onset atrial fibrillation ( 28460022 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) PR interval ( 32439900 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: NEK1	None recorded
Interacting Genes		19 interacting genes: CENPB COPS5 DNMT3L EP300 FAM90A1 GATA4 HAND1 HEY2 HEYL KANK2 NPM1 PHOX2A PPP2R5D PRKACA PRKCA RIPPLY1 SPANXN3 TCF3 USP20	5 interacting genes: ATF6B CREBBP HAND2 JUN PRKACA
Entrez ID		9464	401
HPRD ID		03872	04129
Ensembl ID		ENSG00000164107	ENSG00000165462
Uniprot IDs		P61296	O14813
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Cardiac Septum Morphogenesis Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cardiac Ventricle Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription By RNA Polymerase II Atrioventricular Valve Formation Mesenchymal Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Anterior/posterior Pattern Specification Heart Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Fate Commitment DNA-binding Transcription Factor Binding Protein Dimerization Activity Nucleoplasm DNA-binding Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Cardiac Right Ventricle Morphogenesis Heart Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Nucleus System Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Tissue Development	Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Embryonic Digit Morphogenesis Transcription Coactivator Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Cellular Response To Stress Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of Signaling Histone H3K27 Acetyltransferase Activity Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of ATF6-mediated Unfolded Protein Response Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulator Complex Leading Edge Cell Differentiation Primary Palate Development Positive Regulation Of Semaphorin-plexin Signaling Pathway Cell Proliferation Involved In Outflow Tract Morphogenesis Visceral Serous Pericardium Development Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Intracellular Signal Transduction Cellular Response To Anisomycin Regulation Of Osteoblast Differentiation Regulation Of Semaphorin-plexin Signaling Pathway Intracellular Signaling Cassette Regulation Of ATF6-mediated Unfolded Protein Response Response To Anisomycin Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis