TJP1 and UBN1

Number of citations of the paper that reports this interaction (PubMedID 18823282)
0

Data Source:
HPRD (in vivo)

		TJP1	UBN1
Description		tight junction protein 1	ubinuclein 1
Image
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction	Nucleus Nucleoplasm Bicellular Tight Junction Nuclear Body PML Body Centriolar Satellite Anchoring Junction
	Molecular Function	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding	DNA Binding Protein Binding
	Biological Process	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly	Chromatin Organization Nucleosome Assembly
Pathways		Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Night sleep phenotypes ( 27126917) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3	3 interacting genes: H3-3A TJP1 USP7
Entrez ID		7082	29855
HPRD ID		03002	11660
Ensembl ID		ENSG00000104067	ENSG00000118900
Uniprot IDs		A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157	Q9NPG3
PDB IDs		2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX	4ZBJ
Enriched GO Terms of Interacting Partners?		Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process	Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation Negative Regulation Of Gene Expression, Epigenetic Protein-containing Complex Pericentric Heterochromatin Formation Barr Body Regulation Of Chromosome Organization Regulation Of Organelle Organization Epigenetic Regulation Of Gene Expression Protein Localization To Bicellular Tight Junction Positive Regulation Of Blood-brain Barrier Permeability Adherens Junction Maintenance Ameloblast Differentiation Protein Localization To Adherens Junction Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Blood-brain Barrier Permeability Monoubiquitinated Protein Deubiquitination Subtelomeric Heterochromatin Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Regulation Of Chromosome Condensation Regulation Of Telomere Capping Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Cellular Component Assembly Positive Regulation Of Vascular Permeability Organelle Organization Regulation Of Cellular Component Organization Inner Kinetochore Protein Localization To Cell-cell Junction Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cell-cell Junction Maintenance Regulation Of Bicellular Tight Junction Assembly Oocyte Maturation Chromatin Remodeling Deubiquitinase Activity Chromosome Gap Junction Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cellular Component Organization Apical Junction Complex Negative Regulation Of Stress Fiber Assembly Maintenance Of Blood-brain Barrier Negative Regulation Of Actin Filament Bundle Assembly
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