TJP1 and CLDN3

Number of citations of the paper that reports this interaction (PubMedID 10601346)
52

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TJP1	CLDN3
Description		tight junction protein 1	claudin 3
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly	Response To Hypoxia Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Cell Junction Assembly Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Maintenance Response To Ethanol Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Response To Gram-positive Bacterium Regulation Of Transepithelial Transport Negative Regulation Of Phosphate Transmembrane Transport
Pathways		Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction	Tight junction interactions
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)	Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3	7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4
Entrez ID		7082	1365
HPRD ID		03002	04219
Ensembl ID		ENSG00000104067	ENSG00000165215
Uniprot IDs		A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157	O15551 Q75L79
PDB IDs		2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process	Regulation Of Bicellular Tight Junction Assembly Regulation Of Cell Junction Assembly Bicellular Tight Junction Maintenance Of Blood-brain Barrier Tight Junction Multicellular Organismal-level Homeostasis Homeostatic Process Positive Regulation Of Bicellular Tight Junction Assembly Cell Adhesion Establishment Of Endothelial Intestinal Barrier Cell-cell Junction Assembly Anchoring Junction Response To Lead Ion Cell Junction Organization Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Cell Junction Establishment Of Endothelial Barrier Endothelial Cell Development System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Vascular Permeability Cell Junction Assembly Bicellular Tight Junction Assembly Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein-containing Complex Cell Junction Maintenance Tight Junction Assembly Tight Junction Organization Positive Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Cellular Component Maintenance Lateral Plasma Membrane Xenobiotic Transport Across Blood-nerve Barrier Aldosterone Secretion Regulation Of ATP Metabolic Process Membrane Regulation Of Cell Migration Cell Body
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