TJP1 and TRPC4

Number of citations of the paper that reports this interaction (PubMedID 15540229)
0

Data Source:
HPRD (in vivo, in vitro)

		TJP1	TRPC4
Description		tight junction protein 1	transient receptor potential cation channel subfamily C member 4
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GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction	Plasma Membrane Caveola Cell-cell Junction Cell Surface Membrane Basolateral Plasma Membrane Cortical Cytoskeleton Protein-containing Complex Cation Channel Complex Calcium Channel Complex Membrane Raft
	Molecular Function	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Secretion Monoatomic Ion Transmembrane Transport Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction	TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)	Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3	10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 NHERF1 TJP1 TRPC1 TRPC5
Entrez ID		7082	7223
HPRD ID		03002	09154
Ensembl ID		ENSG00000104067	ENSG00000133107
Uniprot IDs		A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157	Q9UBN4
PDB IDs		2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX	8WPL 8WPM 8WPN
Enriched GO Terms of Interacting Partners?		Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process	Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Ion Transmembrane Transport Calcium Channel Activity Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Metal Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Monoatomic Ion Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Cation Transport Inorganic Ion Homeostasis Calcium Ion Homeostasis Monoatomic Ion Transport Calcium Ion Transmembrane Import Into Cytosol Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport Inorganic Ion Transmembrane Transport Homeostatic Process Monoatomic Ion Transmembrane Transport Plasma Membrane Chemical Homeostasis Intracellular Calcium Ion Homeostasis Transport Vesicle Membrane Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Intracellular Chemical Homeostasis Sarcoplasmic Reticulum Phospholipase C-activating Dopamine Receptor Signaling Pathway Store-operated Calcium Channel Activity Apical Part Of Cell Cellular Homeostasis Calcium Ion Transmembrane Transporter Activity Secretory Granule Membrane Phosphatidylinositol Binding Cellular Response To Ethanol G Protein-coupled Receptor Signaling Pathway Cation Channel Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Membrane Acid Secretion Calcium-mediated Signaling Receptor Complex
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