TJP1 and CGN

Number of citations of the paper that reports this interaction (PubMedID 10613913)
68

Data Source:
HPRD (in vitro, in vivo)

		TJP1	CGN
Description		tight junction protein 1	cingulin
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction Anchoring Junction
	Molecular Function	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding	Actin Binding Protein Binding Microtubule Binding Cadherin Binding
	Biological Process	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly	Microtubule Cytoskeleton Organization
Pathways		Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)	Body mass index ( 26426971)
Interacting Genes		40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3	10 interacting genes: ARHGEF2 CDC42 F11R LNX1 PPP1R13B RNF10 TJP1 TJP2 TP53BP2 YWHAG
Entrez ID		7082	57530
HPRD ID		03002	10827
Ensembl ID		ENSG00000104067	ENSG00000143375
Uniprot IDs		A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157	Q9P2M7
PDB IDs		2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process	Establishment Of Endothelial Intestinal Barrier Protein Localization To Cell-cell Junction Maintenance Of Blood-brain Barrier Tight Junction Establishment Of Endothelial Barrier Bicellular Tight Junction Endothelial Cell Development Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Protein Localization To Cell Junction Regulation Of Stress Fiber Assembly Positive Regulation Of Vascular Permeability Regulation Of Supramolecular Fiber Organization Epithelial Cell Development Anchoring Junction Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Cell Junction Organization Cell-cell Junction Organization Positive Regulation Of Cell Adhesion Intestinal Absorption Anatomical Structure Homeostasis Tissue Homeostasis Negative Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Intracellular Protein Localization Cell Junction Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Vascular Permeability Regulation Of Actin Filament Organization Adherens Junction Organization Negative Regulation Of Cellular Component Organization Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein-containing Complex Cadherin Binding Regulation Of Membrane Permeability Circulatory System Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion P53 Binding Regulation Of Actin Cytoskeleton Organization Digestive System Process Ubiquitin Protein Ligase Activity Actin Cytoskeleton Organization PDZ Domain Binding Regulation Of Actin Filament-based Process Apical Part Of Cell GBD Domain Binding
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