SYTL5 and RAB27A

Number of citations of the paper that reports this interaction (PMID 12051743)
12

Data Source:
HPRD (in vivo, in vitro)

		SYTL5	RAB27A
Gene Name		synaptotagmin-like 5	RAB27A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Rab GTPase Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Exocytosis	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		6 interactors: CEP70 RAB27A RAB27B RAB3A RAB6A WAC	28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		94122	5873
HPRD ID		06736	04845
Ensembl ID		ENSG00000147041	ENSG00000069974
Uniprot IDs		Q8TDW5	A2RU94 P51159
PDB IDs
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Protein Secretion Regulation Of Exocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Regulated Secretory Pathway Establishment Of Vesicle Localization Vesicle Localization Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Intracellular Protein Transport Melanosome Localization Regulation Of Regulated Secretory Pathway Establishment Of Organelle Localization Positive Regulation Of Secretion Exocytosis Regulation Of Vesicle-mediated Transport Cellular Pigmentation Organelle Localization Cellular Protein Localization Protein Transport Secretion By Cell Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Histone H2B Conserved C-terminal Lysine Ubiquitination Synaptic Vesicle Transport Pigmentation Secretion Regulation Of Secretion Multivesicular Body Organization Cytotoxic T Cell Degranulation Intracellular Signal Transduction Positive Regulation Of Transport Protein Localization Establishment Of Localization In Cell Constitutive Secretory Pathway Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Sensory Perception Of Touch	Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization
Tagcloud ?			adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?			adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?