SYTL5 and RAB3A

Number of citations of the paper that reports this interaction (PMID 12051743)
12

Data Source:
HPRD (in vitro, in vivo)

		SYTL5	RAB3A
Gene Name		synaptotagmin-like 5	RAB3A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Acrosomal Vesicle Endosome Cytosol Plasma Membrane Synaptic Vesicle Axon Secretory Granule Membrane Vesicle Terminal Bouton Protein Complex Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Protein Binding Rab GTPase Binding Metal Ion Binding	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding GDP Binding Myosin V Binding GTPase Binding ATPase Binding
	Biological Process	Intracellular Protein Transport Exocytosis	Respiratory System Process Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Mitochondrion Organization Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axonogenesis Protein Secretion Post-embryonic Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Rab Protein Signal Transduction Positive Regulation Of ATPase Activity Synaptic Vesicle Recycling Constitutive Secretory Pathway Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Regulated Secretory Pathway
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		6 interactors: CEP70 RAB27A RAB27B RAB3A RAB6A WAC	24 interactors: A2M ADRB2 AP1M2 APP CASK CHM CHML DMXL2 ECSIT EGFR MAST1 PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF RIMS1 RIMS2 RNF32 RPH3A RPH3AL SYTL4 SYTL5
Entrez ID		94122	5864
HPRD ID		06736	01535
Ensembl ID		ENSG00000147041	ENSG00000105649
Uniprot IDs		Q8TDW5	P20336
PDB IDs
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Protein Secretion Regulation Of Exocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Regulated Secretory Pathway Establishment Of Vesicle Localization Vesicle Localization Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Intracellular Protein Transport Melanosome Localization Regulation Of Regulated Secretory Pathway Establishment Of Organelle Localization Positive Regulation Of Secretion Exocytosis Regulation Of Vesicle-mediated Transport Cellular Pigmentation Organelle Localization Cellular Protein Localization Protein Transport Secretion By Cell Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Histone H2B Conserved C-terminal Lysine Ubiquitination Synaptic Vesicle Transport Pigmentation Secretion Regulation Of Secretion Multivesicular Body Organization Cytotoxic T Cell Degranulation Intracellular Signal Transduction Positive Regulation Of Transport Protein Localization Establishment Of Localization In Cell Constitutive Secretory Pathway Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Sensory Perception Of Touch	Establishment Of Protein Localization Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Transport Intracellular Transport Cellular Protein Localization Exocytosis Intracellular Protein Transport Secretion Secretion By Cell Transport Vesicle-mediated Transport Protein Geranylgeranylation Regulation Of Catalytic Activity Protein Prenylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Hydrolase Activity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Inhibitory Postsynaptic Membrane Potential Membrane Organization Neurotransmitter Secretion Regulation Of Signaling Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Binding Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Exocytosis Positive Regulation Of GTPase Activity Neurological System Process Endoplasmic Reticulum Calcium Ion Homeostasis Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Organelle Localization Visual Perception Membrane Hyperpolarization Regulation Of GTPase Activity Sensory Perception Of Light Stimulus Vesicle Targeting Positive Regulation Of Membrane Potential Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Vesicle Localization Regulation Of Vasodilation
Tagcloud ?			abundant adenohypophyseal anterior att cellubrevin corticotroph endocrine exocytosis fractionation fractions granules immunoblotting immunocytochemical isoform location microvesicles organelles pituitary represented secretory snap subcellular synaptic synaptobrevin synaptophysin synaptotagmin syntaxin took vesicles
Tagcloud (Difference) ?			abundant adenohypophyseal anterior att cellubrevin corticotroph endocrine exocytosis fractionation fractions granules immunoblotting immunocytochemical isoform location microvesicles organelles pituitary represented secretory snap subcellular synaptic synaptobrevin synaptophysin synaptotagmin syntaxin took vesicles
Tagcloud (Intersection) ?