SYTL5 and WAC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SYTL5	WAC
Description		synaptotagmin like 5	WW domain containing adaptor with coiled-coil
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Exocytic Vesicle	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Protein Binding Phospholipid Binding Zinc Ion Binding Small GTPase Binding Neurexin Family Protein Binding Metal Ion Binding	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	Intracellular Protein Transport Exocytosis	Chromatin Organization Chromatin Remodeling DNA Damage Response Regulation Of Autophagy Positive Regulation Of Macroautophagy Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of TORC1 Signaling
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457) Erectile dysfunction and prostate cancer treatment ( 20932654)	Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma ( 27363682)
Interacting Genes		8 interacting genes: CCDC85A CEP70 RAB27A RAB3A RAB6A TRIM54 WAC YIF1A	29 interacting genes: AKAP9 APP BACH1 CCDC6 CDC37 CDK1 CRKL DYDC1 HMG20B KLC3 KRT15 LNX1 MOBP MTUS2 NDE1 NFE2L2 PLK1 SYTL5 TFIP11 TNS2 TRAF1 TRAF3IP1 TRAF3IP3 TTC3 UBC UBQLN4 VCP VCPIP1 ZDHHC17
Entrez ID		94122	51322
HPRD ID		06736	18291
Ensembl ID		ENSG00000147041	ENSG00000095787
Uniprot IDs		Q8TDW5	Q9BTA9
PDB IDs
Enriched GO Terms of Interacting Partners?		Myosin V Binding Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Regulated Secretory Pathway GTPase Activity Synaptic Vesicle Transport GTP Binding Establishment Of Organelle Localization Evoked Neurotransmitter Secretion Peptidyl-cysteine Methylation Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein Localization To Extracellular Region Organelle Localization Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Vesicle-mediated Transport Regulated Exocytosis Positive Regulation Of Exocytosis Protein Transport Establishment Of Protein Localization To Extracellular Region Protein Secretion Vesicle Localization Regulation Of Dense Core Granule Exocytosis Secretory Granule Membrane Sensory Perception Of Touch Establishment Of Vesicle Localization Antigen Processing And Presentation Endosome To Plasma Membrane Transport Vesicle Complement-dependent Cytotoxicity Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Clathrin-sculpted Glutamate Transport Vesicle Membrane Minus-end-directed Organelle Transport Along Microtubule Exosomal Secretion Acrosomal Vesicle Exocytosis Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Microtubule Cytoskeleton Organization Constitutive Secretory Pathway Protein Localization To Golgi Membrane Weibel-Palade Body Regulation Of Exocytosis Regulation Of Plasma Membrane Repair Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Natural Killer Cell Degranulation Establishment Of Localization In Cell Synaptic Vesicle Maturation Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Maintenance Of Presynaptic Active Zone Structure Exocytosis Presynaptic Active Zone Organization Protein Domain Specific Binding	Cytoplasm Post-translational Protein Modification Protein Modification By Small Protein Conjugation Response To Copper Ion Microtubule-based Process Identical Protein Binding Protein Modification Process Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Protein Ubiquitination Microtubule Binding Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Mitotic Nuclear Membrane Disassembly DNA Metabolic Process DNA Repair Centrosome Separation Transport Along Microtubule Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nuclear Membrane Disassembly Cytoskeleton-dependent Intracellular Transport Membrane Disassembly Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Microtubule-based Transport Cellular Response To Copper Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Microtubule Cytoskeleton Organization Protein Localization To Site Of Double-strand Break Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Cytoskeleton Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium
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