LCP2 and FYB

Number of citations of the paper that reports this interaction (PMID 9207119)
62

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LCP2	FYB
Gene Name		lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	FYN binding protein
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction	Nucleus Cytosol Actin Cytoskeleton
	Molecular Function	Protein Binding	Receptor Binding Protein Binding Protein Complex Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Platelet Activation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Mast Cell Activation Cytokine Secretion T Cell Receptor Signaling Pathway	Protein Phosphorylation NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Biological_process Intracellular Signal Transduction T Cell Receptor Signaling Pathway
Pathways		DAP12 interactions Generation of second messenger molecules FCERI mediated MAPK activation DAP12 signaling TCR signaling GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Innate Immune System Adaptive Immune System	TCR signaling Generation of second messenger molecules Signal regulatory protein (SIRP) family interactions Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		39 interactors: APP BLNK CBL CD22 CLNK FXR2 FYB FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LYN MAP4K1 NCK1 NCK2 PAG1 PIK3R1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAZ ZAP70	14 interactors: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 SH2D1A SKAP1 SKAP2 SRC VASP WAS
Entrez ID		3937	2533
HPRD ID		03362	04107
Ensembl ID			ENSG00000082074
Uniprot IDs		Q13094	O15117 Q05DE9
PDB IDs		1H3H 1YWO 2EAP 2ROR	1RI9 2GTJ 2GTO
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Activation Immune System Process Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Innate Immune Response Defense Response Fc-epsilon Receptor Signaling Pathway Platelet Activation Regulation Of Signal Transduction Leukocyte Activation Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Signaling Blood Coagulation Signal Transduction Hemostasis Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Signaling Leukocyte Migration Lymphocyte Activation Cell Communication Positive Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Body Fluid Levels Positive Regulation Of Cell Adhesion Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation	T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Signaling Cell Communication Actin Filament Organization Signal Transduction Cell Activation Actin Polymerization Or Depolymerization Response To Stimulus Cellular Response To Stimulus Chemotaxis Actin Cytoskeleton Organization Actin Filament-based Process Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Immune Response Platelet Activation Leukocyte Activation Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Response To Growth Factor Wound Healing Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Neuron Projection Morphogenesis Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Response To Wounding Cell Morphogenesis Involved In Differentiation Locomotion Regulation Of Cellular Component Organization
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib
Tagcloud (Intersection) ?