LCP2 and PAG1

Number of citations of the paper that reports this interaction (PMID 10790433)
107

Data Source:
HPRD (in vitro)

		LCP2	PAG1
Gene Name		lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction	Plasma Membrane Integral Component Of Membrane Membrane Raft
	Molecular Function	Protein Binding	SH3/SH2 Adaptor Activity Protein Binding SH2 Domain Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Platelet Activation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Mast Cell Activation Cytokine Secretion T Cell Receptor Signaling Pathway	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Negative Regulation Of T Cell Activation
Pathways		DAP12 interactions Generation of second messenger molecules FCERI mediated MAPK activation DAP12 signaling TCR signaling GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Innate Immune System Adaptive Immune System	Signaling by EGFR TCR signaling GAB1 signalosome Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Serum total protein level ( 23022100)
Protein-Protein Interactions		39 interactors: APP BLNK CBL CD22 CLNK FXR2 FYB FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LYN MAP4K1 NCK1 NCK2 PAG1 PIK3R1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAZ ZAP70	17 interactors: ABL1 CSK FYN GLS2 GRB2 HTRA2 LCK LCP2 LYN PTPN11 PTPN6 RASA1 SHC1 SLC9A3R1 SYK VAV1 ZAP70
Entrez ID		3937	55824
HPRD ID		03362	05772
Ensembl ID			ENSG00000076641
Uniprot IDs		Q13094	Q9NWQ8
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Activation Immune System Process Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Innate Immune Response Defense Response Fc-epsilon Receptor Signaling Pathway Platelet Activation Regulation Of Signal Transduction Leukocyte Activation Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Signaling Blood Coagulation Signal Transduction Hemostasis Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Signaling Leukocyte Migration Lymphocyte Activation Cell Communication Positive Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Body Fluid Levels Positive Regulation Of Cell Adhesion Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Immune Response-activating Cell Surface Receptor Signaling Pathway Hemostasis Enzyme Linked Receptor Protein Signaling Pathway Platelet Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Innate Immune Response T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Regulation Of Body Fluid Levels Peptidyl-tyrosine Autophosphorylation Wound Healing Regulation Of Immune Response Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cell Activation Response To Wounding Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cell Migration Regulation Of Lymphocyte Activation Cell Motility Positive Regulation Of Immune System Process Locomotion Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Immune Response Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Defense Response Regulation Of Cell Activation Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Intracellular Signal Transduction
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	adaptor cbp cpg deacetylase egf epigenetic h4 harboring hdac hdac1 hypomethylation inactivation inhibiting inversely islands mapk mek modifications oncogenic pi3k restored src subset suppressed suppressor transformation transformed transmembrane trimethylation
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	adaptor cbp cpg deacetylase egf epigenetic h4 harboring hdac hdac1 hypomethylation inactivation inhibiting inversely islands mapk mek modifications oncogenic pi3k restored src subset suppressed suppressor transformation transformed transmembrane trimethylation
Tagcloud (Intersection) ?