LCP2 and PAG1

Number of citations: 63 (PubMedID 10790433)
Data Source: HPRD (in vitro)

		LCP2	PAG1
Name		lymphocyte cytosolic protein 2	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Plasma Membrane Membrane Membrane Raft
	Molecular Function	Protein Binding	Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Adaptive Immune Response Immune System Process Signal Transduction Intracellular Signal Transduction Regulation Of T Cell Activation Negative Regulation Of T Cell Activation
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains
GWAS		Acne (severe) ( 24927181 ) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )	Aspartate aminotransferase levels ( 33547301 ) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699 ) Health literacy ( 31250787 ) Serum total protein levels ( 23022100 )
Interacting Genes		48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	17 interacting genes: ABL1 CSK FYN GLS2 GRB2 HTRA2 LCK LCP2 LYN NHERF1 PTPN11 PTPN6 RASA1 SHC1 SYK VAV1 ZAP70
Entrez ID		3937	55824
HPRD ID		03362	05772
Ensembl ID		ENSG00000043462	ENSG00000076641
Uniprot IDs		Q13094	Q9NWQ8
PDB IDs		1H3H 1YWO 2EAP 2ROR 6ZCJ	Not available
GO Terms Enriched among Interactors		Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Signal Transduction Cell Activation Regulation Of MAPK Cascade Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Activation Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Membrane Raft Ephrin Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Regulation Of Signaling	Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Fc-gamma Receptor Signaling Pathway Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Ephrin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Lymphocyte Activation T Cell Activation Regulation Of Signal Transduction Cell-cell Junction Positive Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Immune Effector Process Regulation Of Immune System Process