LCP2 and ELOVL6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LCP2	ELOVL6
Name		lymphocyte cytosolic protein 2	ELOVL fatty acid elongase 6
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongase Complex Membrane
	Molecular Function	Protein Binding	Protein Binding Fatty Acid Elongase Activity Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
	Biological Process	Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Activation of gene expression by SREBF (SREBP) Synthesis of very long-chain fatty acyl-CoAs
GWAS		Acne (severe) ( 24927181 ) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )	Attention deficit hyperactivity disorder ( 20732626 ) Benign prostatic hyperplasia ( 30988330 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Obesity-related traits ( 23251661 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite levels ( 33031748 )
Interacting Genes		48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	3 interacting genes: HMOX1 LCP2 RTP2
Entrez ID		3937	79071
HPRD ID		03362	13269
Ensembl ID		ENSG00000043462	ENSG00000170522
Uniprot IDs		Q13094	Q9H5J4
PDB IDs		1H3H 1YWO 2EAP 2ROR 6ZCJ	Not available
GO Terms Enriched among Interactors		Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Signal Transduction Cell Activation Regulation Of MAPK Cascade Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Activation Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Membrane Raft Ephrin Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Regulation Of Signaling	Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response TCR Signalosome Cellular Response To Cisplatin Olfactory Receptor Binding Response To Cisplatin Smooth Muscle Adaptation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Porphyrin-containing Compound Catabolic Process Erythrocyte Homeostasis Heme Catabolic Process Mast Cell Activation Negative Regulation Of Ferroptosis Low-density Lipoprotein Particle Clearance Regulation Of Ferroptosis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Positive Regulation Of Epithelial Cell Apoptotic Process Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Multicellular Organismal-level Iron Ion Homeostasis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Plasma Lipoprotein Particle Clearance Response To Arsenic-containing Substance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Myeloid Cell Homeostasis Endothelial Cell Proliferation Negative Regulation Of Macroautophagy Heme Metabolic Process Plasma Membrane Raft