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LCP2
Description
lymphocyte cytosolic protein 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cell-cell Junction
TCR Signalosome
Plasma Membrane Raft
Molecular Function
Protein Binding
Biological Process
Immune System Process
Immune Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Mast Cell Activation
Positive Regulation Of Protein Kinase Activity
T Cell Receptor Signaling Pathway
Pathways
GPVI-mediated activation cascade
Generation of second messenger molecules
Generation of second messenger molecules
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS
Acne (severe) (
24927181
)
Body mass index and diastolic blood pressure (bivariate analysis) (
33539483
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Liver transplant-free survival in primary sclerosing cholangitis (time to event) (
28779025
)
Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) (
26503814
)
Novel Interacting Genes
2 novel interacting genes:
GALNT10
LARP1
Interacting Genes
48 interacting genes:
APP
BLNK
CBL
CD22
CLNK
EGFR
ELOVL6
ERBB2
ERBB3
ERBB4
FXR2
FYB1
FYN
GOLGA2
GRAP2
GRB2
HCK
ITK
LAT
LCK
LMNA
LNX1
LYN
MAP4K1
NCK1
NCK2
PAG1
PJA1
PLCG1
PLCG2
PRAM1
PTPN6
PTPRC
SH3GL2
SH3RF1
SHB
SHC1
STAM2
SYK
TRAT1
TXK
VAV1
VAV3
WAS
YBX1
YWHAE
YWHAZ
ZAP70
Entrez ID
3937
HPRD ID
03362
Ensembl ID
ENSG00000043462
Uniprot IDs
Q13094
PDB IDs
1H3H
1YWO
2EAP
2ROR
6ZCJ
Enriched GO Terms of Interacting Partners
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Immune Response-activating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Phosphotyrosine Residue Binding
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune System Process
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Intracellular Signal Transduction
Leukocyte Activation
Signal Transduction
Cell Activation
Regulation Of MAPK Cascade
Regulation Of Lymphocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of Cell Activation
Positive Regulation Of Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of T Cell Activation
Peptidyl-tyrosine Phosphorylation
Fc Receptor Signaling Pathway
Intracellular Signaling Cassette
T Cell Activation
Positive Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Multicellular Organismal Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Membrane Raft
Ephrin Receptor Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Signal Transduction
Positive Regulation Of Cell Activation
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Lymphocyte Activation
Negative Regulation Of Immune System Process
Regulation Of Signaling
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